Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''FMNL3''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The protein encoded by this gene contains a
formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different
isoform
A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences. While many perform the same or similar biological roles, some iso ...
s have been described.
The C-terminus has been shown to accelerate actin polymerization activity of this protein through its
WH2-like motif. FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.
See also
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FMNL1
Formin-like protein 1 is a protein that in humans is encoded by the ''FMNL1'' gene.
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice v ...
*
FMNL2
Formin-like protein 2 is a protein that in humans is encoded by the ''FMNL2'' gene.
Expression
Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described. The full length FMNL2 (FRL3) protein (10 ...
References
Further reading
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