FK506-binding protein 2 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the ''FKBP2''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Function

The

encoded by this gene is a member of the

immunophilin In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases (PPI) that catalyze the interconversion between the Cis–trans isomerism, cis and trans isomers of peptide bonds containing the amino acid proline (Pro). They ...

protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a

cis-trans prolyl isomerase Prolyl isomerase (also known as peptidylprolyl isomerase or PPIase) is an enzyme () found in both prokaryotes and eukaryotes that interconverts the ''cis'' and ''trans'' isomers of peptide bonds with the amino acid proline. Proline has an unusua ...

that binds the immunosuppressants FK506 and

rapamycin Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, ...

. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple

polyadenylation Polyadenylation is the addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA). The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In euk ...

sites have been described for this gene, but the full length nature of this gene has not been determined.

Interactions

FKBP2 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with

ARFGEF1 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ''ARFGEF1'' gene. Function ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein enc ...

and

EPB41L2 Band 4.1-like protein 2 is a protein that in humans is encoded by the ''EPB41L2'' gene. Interactions EPB41L2 has been shown to interact with FKBP2 and GRIA1 Glutamate receptor 1 is a protein that in humans is encoded by the ''GRIA1'' gene. ...

Function

Interactions

References

Further reading