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F. Mason Sones, Jr. (October 28, 1918 – August 28, 1985) was an American physician whose pioneering work in
cardiac catheterization Cardiac catheterization (heart cath) is the insertion of a catheter into a chamber or vessel of the heart. This is done both for diagnostic and interventional purposes. A common example of cardiac catheterization is coronary catheterization that ...
was instrumental in the development of both
coronary artery bypass surgery Coronary artery bypass surgery, also known as coronary artery bypass graft (CABG, pronounced "cabbage") is a surgical procedure to treat coronary artery disease (CAD), the buildup of plaques in the arteries of the heart. It can relieve chest pai ...
and
interventional cardiology Interventional cardiology is a branch of cardiology that deals specifically with the catheter based treatment of structural heart diseases. Andreas Gruentzig is considered the father of interventional cardiology after the development of angioplasty ...
.


Early life and career

Sones was born in Noxapater,
Mississippi Mississippi () is a state in the Southeastern region of the United States, bordered to the north by Tennessee; to the east by Alabama; to the south by the Gulf of Mexico; to the southwest by Louisiana; and to the northwest by Arkansas. Miss ...
Westaby, p. 214 to Frank Mason and Myrtle (Bryan) Sones. He graduated from
Western Maryland College McDaniel College is a private college in Westminster, Maryland. Established in 1867, it was known as Western Maryland College until 2002 when it was renamed McDaniel College in honor of an alumnus who gave a lifetime of service to the college. ...
(now McDaniel College) in 1940 and received his M.D. from the
University of Maryland School of Medicine The University of Maryland School of Medicine (abbreviated UMSOM), located in Baltimore City, Maryland, U.S., is the medical school of the University of Maryland, Baltimore and is affiliated with the University of Maryland Medical Center and Me ...
in 1943. In 1942, Sones married Geraldine Newton. The couple had four children, Frank Mason III, Geraldine Patricia, Steven, and David. From 1944 to 1946, he served in the
United States Army Air Corps The United States Army Air Corps (USAAC) was the aerial warfare service component of the United States Army between 1926 and 1941. After World War I, as early aviation became an increasingly important part of modern warfare, a philosophical r ...
in the Pacific and would later serve as a national consultant to the Air Force. Sones served as an
intern An internship is a period of work experience offered by an organization for a limited period of time. Once confined to medical graduates, internship is used practice for a wide range of placements in businesses, non-profit organizations and gover ...
at University Hospital in
Baltimore Baltimore ( , locally: or ) is the List of municipalities in Maryland, most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic (United States), Mid-Atlantic, and List of United States cities by popula ...
and was a
Resident Resident may refer to: People and functions * Resident minister, a representative of a government in a foreign country * Resident (medicine), a stage of postgraduate medical training * Resident (pharmacy), a stage of postgraduate pharmaceuti ...
at
Henry Ford Hospital Henry Ford Hospital (HFH) is an 877-bed tertiary care hospital, education and research complex at the western edge of the New Center area in Detroit, Michigan. The flagship facility for the Henry Ford Health System, it was one of the first hos ...
in
Detroit Detroit ( , ; , ) is the largest city in the U.S. state of Michigan. It is also the largest U.S. city on the United States–Canada border, and the seat of government of Wayne County. The City of Detroit had a population of 639,111 at th ...
before joining the Cleveland Clinic Foundation in 1950.


Discovery of coronary angiography

While at Henry Ford, Sones had learned the techniques of cardiac catheterization and his first appointment at the Cleveland Clinic was as head of
Pediatric Pediatrics ( also spelled ''paediatrics'' or ''pædiatrics'') is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, paediatrics covers many of their youth until the ...
Cardiology. On October 30, 1958, while working in the Cardiac Laboratory on a 26-year-old patient with
rheumatic heart disease Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The disease typically develops two to four weeks after a streptococcal throat infection. Signs and symptoms include fever, multiple painful jo ...
, Sones was performing a procedure in which
contrast dye Radiocontrast agents are substances used to enhance the visibility of internal structures in X-ray-based imaging techniques such as computed tomography (contrast CT), projectional radiography, and fluoroscopy. Radiocontrast agents are typically io ...
was to be injected into the man's
aorta The aorta ( ) is the main and largest artery in the human body, originating from the left ventricle of the heart and extending down to the abdomen, where it splits into two smaller arteries (the common iliac arteries). The aorta distributes ...
. Just before the dye injection, Sones noticed that the catheter tip had inadvertently entered the man's
right coronary artery In the blood supply of the heart, the right coronary artery (RCA) is an artery originating above the right cusp of the aortic valve, at the right aortic sinus in the heart. It travels down the right coronary sulcus, towards the crux of the hear ...
. Sones asked that the catheter be withdrawn, but before that could be accomplished, a large amount of dye was injected directly into the artery. Sones expected the man's heart to go into
fibrillation Fibrillation is the rapid, irregular, and unsynchronized contraction of muscle fibers. An important occurrence is with regard to the heart. Cardiology There are two major classes of cardiac fibrillation: atrial fibrillation and ventricular fib ...
and prepared to do an emergency open chest massage. But instead of fibrillating, the man's heart went into
asystole Asystole (New Latin, from Greek privative a "not, without" + ''systolē'' "contraction") is the absence of ventricular contractions in the context of a lethal heart arrhythmia (in contrast to an induced asystole on a cooled patient on a heart-lun ...
, and Sones shouted at him to cough, which successfully restarted the heart beating. From this experience, Sones realized that smaller amounts of contrast dye ''could'' safely be injected directly into coronary arteries, giving
cardiologists Cardiology () is a branch of medicine that deals with disorders of the heart and the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular heart d ...
accurate pictures of arterial blockages for the first time. Sones subsequently studied video engineering, dye chemistry, and optical image amplification to perfect the procedure. In 1967, Sones's Cleveland Clinic colleague, Dr.
René Favaloro René Gerónimo Favaloro (July 12, 1923 – July 29, 2000) was an Argentine cardiac surgeon and educator best known for his pioneering work on coronary artery bypass surgery using the great saphenous vein. Early life Favaloro was born in 192 ...
, performed the world's first
coronary bypass surgery Coronary artery bypass surgery, also known as coronary artery bypass graft (CABG, pronounced "cabbage") is a surgical procedure to treat coronary artery disease (CAD), the buildup of plaques in the arteries of the heart. It can relieve chest p ...
. Dr Favaloro called Sones "the most important contributor to modern cardiology" and said that without his work, "all our efforts in myocardial revascularization would have been fruitless."


Later career and awards

Sones was the Director of the Cleveland Clinic Department of Cardiovascular Disease from 1966 to 1975, and later served as senior physician of the Department of Cardiology. Sones was honored with numerous awards during his career, including the
American Medical Association The American Medical Association (AMA) is a professional association and lobbying group of physicians and medical students. Founded in 1847, it is headquartered in Chicago, Illinois. Membership was approximately 240,000 in 2016. The AMA's state ...
's 1978 Scientific Achievement Award and the
Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a p ...
in 1969. In 1973 he was awarded the
Texas Heart Institute The Texas Heart Institute is an independent, nonprofit organization that is improving cardiovascular health through trailblazing research, thought leadership, education, and patient care to forge a better future for those with cardiovascular diseas ...
's Ray C. Fish Award. He was a leading participant in the founding of the Society for Cardiac Angiography (now known as the Society for Cardiovascular Angiography and Interventions) and was its first president. Sones died of lung cancer on August 28, 1985, in Cleveland, at the age of 66, and was buried in Chagrin Falls, Ohio - Evergreen Cemetery.


References


Sources

* * * {{DEFAULTSORT:Sones, F. Mason 1918 births 1985 deaths American cardiac surgeons University of Maryland, Baltimore alumni Recipients of the Lasker-DeBakey Clinical Medical Research Award People from Winston County, Mississippi Cleveland Clinic people 20th-century surgeons Western Maryland College alumni