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The European Physiology Module (EPM) is an
International Standard Payload Rack The International Standard Payload Rack (ISPR) is a steel framework container that is designed and been adopted by the International Space Station (ISS) program to support efficient integration and interchangeability of space payload hardware, ...
for the Columbus Laboratory on board the
International Space Station The International Space Station (ISS) is the largest modular space station currently in low Earth orbit. It is a multinational collaborative project involving five participating space agencies: NASA (United States), Roscosmos (Russia), JAXA ...
. The EPM rack was built by
OHB-System OHB SE is a European multinational technology corporation. Headquartered in Bremen, Germany, the corporation consists of the two business divisions Space Systems and Aerospace + Industrial Products. A key product of the corporation is fully int ...
in
Bremen Bremen (Low German also: ''Breem'' or ''Bräm''), officially the City Municipality of Bremen (german: Stadtgemeinde Bremen, ), is the capital of the German state Free Hanseatic City of Bremen (''Freie Hansestadt Bremen''), a two-city-state consis ...
. The EPM enables a better understanding of the effects of spaceflight on the human body. Research typically includes neuroscientific, cardiovascular, and physiological studies and investigations of metabolic processes. The EPM performs physiological and biomedical tests and transmits the data to Earth for further analysis. The resulting data will provide insight into the human body's processes in a microgravity environment. The EPM provides equipment for the study of the human body, including three science modules: two active modules, CARDIOLAB and MEEMM, and one module (sample collection kit, or SCK) that includes equipment to enable collection of biological samples (blood, urine, and saliva). European Physiology Module (EPM) - NASA


Description

The facility will consist of separate modules in which investigators can install their hardware for study of the human body on ISS. The Cardiolab (CDL) and the Multi Electrodes Encephalogram Measurement Module (MEEMM) will be initially launched with the EPM facility. The European Physiology Module is a double-rack multi-user facility that supports investigations of respiratory and cardiovascular conditions, hormonal and body fluid shift, bone demineralization and neuroscience. The facility is based on a modular design concept to support diverse experiments. Human
physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...
experiments are aimed primarily at increasing our knowledge of how the human body reacts to long-duration weightlessness. However, this area of research also contributes to an increased understanding of terrestrial problems such as the
ageing process Ageing ( BE) or aging ( AE) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In ...
,
osteoporosis Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to bone fragility, and consequent increase in fracture risk. It is the most common reason for a broken bone ...
,
balance disorder A balance disorder is a disturbance that causes an individual to feel unsteady, for example when standing or walking. It may be accompanied by feelings of giddiness, or wooziness, or having a sensation of movement, spinning, or floating. Balance ...
s, and
muscle wasting Muscle atrophy is the loss of skeletal muscle mass. It can be caused by immobility, aging, malnutrition, medications, or a wide range of injuries or diseases that impact the musculoskeletal or nervous system. Muscle atrophy leads to muscle weakness ...
. Typical research areas include: *
Neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, development ...
- Neurovestibular control of posture, balance, and motion sensory coordination *
Cardiovascular The blood circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate. It includes the cardiovascular system, or vascular system, tha ...
and
Respiratory The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies grea ...
Systems - Control of blood volume and distribution; fluid volume shift *Bone and Muscle Physiology - Muscle de-conditioning/atrophy *
Endocrinology Endocrinology (from '' endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental event ...
,
Nutrition Nutrition is the biochemical and physiological process by which an organism uses food to support its life. It provides organisms with nutrients, which can be metabolized to create energy and chemical structures. Failure to obtain sufficient n ...
and
Metabolism Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cell ...
- Hormonal regulation; demineralization To correctly evaluate the on-board data, it is essential that reference (or baseline) data are collected prior to flight and following the return of the crew-members to Earth. For this reason, the EPM facility will provide a Baseline Data Collection Model (BDCM) system that includes functional copies of the on-board instruments. The BDCM will be readily transportable to ensure availability of the equipment for the pre-flight, launch and post-flight activities.


Containers and operation

The European Physiology Module includes the following science containers for medical experiments: * Multi-Electrode Electroencephalography Module (MEEMM) - For
neurologic Neurology (from el, νεῦρον (neûron), "string, nerve" and the suffix -logia, "study of") is the branch of medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the brain, the spinal c ...
scans of the
brain A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a v ...
. (Built by EREMS in
Toulouse Toulouse ( , ; oc, Tolosa ) is the prefecture of the French department of Haute-Garonne and of the larger region of Occitania. The city is on the banks of the River Garonne, from the Mediterranean Sea, from the Atlantic Ocean and from Par ...
.) * Samples Collection Kit (SCK) - Collection of different medical instruments and boxes for biologic probes. * Cardiolab (CDL) - To scan the
cardiovascular system The blood circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate. It includes the cardiovascular system, or vascular system, tha ...
. (Built by CADMOS in
Toulouse Toulouse ( , ; oc, Tolosa ) is the prefecture of the French department of Haute-Garonne and of the larger region of Occitania. The city is on the banks of the River Garonne, from the Mediterranean Sea, from the Atlantic Ocean and from Par ...
.) The EPM is operated according to ESA's decentralised payload operation concept. The
Facility Responsible Centre Facility may refer to: * A place for doing something, or a place that facilitates an activity: ** A commercial or institutional building, such as a hotel, resort, school, office complex, sports arena, or convention center ** Medical facility * ...
(FRC) for the EPM is CADMOS, located in Toulouse, France. The different EPM models are: * Flight Model (FM) - Delivered September 2005 to
EADS SPACE Transportation Astrium was an aerospace manufacturer subsidiary of the European Aeronautic Defence and Space Company (EADS) that provided civil and military space systems and services from 2006 to 2013. In 2012, Astrium had a turnover of €5.8 billion and 18 ...
,
Bremen Bremen (Low German also: ''Breem'' or ''Bräm''), officially the City Municipality of Bremen (german: Stadtgemeinde Bremen, ), is the capital of the German state Free Hanseatic City of Bremen (''Freie Hansestadt Bremen''), a two-city-state consis ...
for integration. * Trainings Model (TRM) - Delivered to the
European Astronaut Centre The European Astronaut Centre (EAC) (German: Europäisches Astronautenzentrum, French: Centre des astronautes européens), is an establishment of the European Space Agency and home of the European Astronaut Corps. It is near to Cologne, Germany ...
(EAC),
ESA , owners = , headquarters = Paris, Île-de-France, France , coordinates = , spaceport = Guiana Space Centre , seal = File:ESA emblem seal.png , seal_size = 130px , image = Views in the Main Control Room (1205 ...
in
Cologne Cologne ( ; german: Köln ; ksh, Kölle ) is the largest city of the German western States of Germany, state of North Rhine-Westphalia (NRW) and the List of cities in Germany by population, fourth-most populous city of Germany with 1.1 m ...
. * Ground Model (GM-1) - Delivered July 2005 to the FRC, CADMOS. * Ground Model (GM-2) - To be delivered in March 2006 to the Lyndon B. Johnson Space Center (JSC),
NASA The National Aeronautics and Space Administration (NASA ) is an independent agency of the US federal government responsible for the civil space program, aeronautics research, and space research. NASA was established in 1958, succeeding t ...
. * Baseline Data Collection Model (BDCM) - Delivered in October 2005 to the FRC, CADMOS.


Gallery

File:398061main_EPM3.jpg, NASA Image: ISS018E032095: The photo shows Human Research Facility (HRF) rack 2; the European Physiology Module (EPM) is visible. Three-dimensional modeling of International Space Station Interior and Exterior project. Taken for PhotoSynth File:186705main_EPM1.jpg, Testing of one of the experiment modules for European Physiology Module (EPM). Image provided by O. Amend.


See also

*
Scientific research on the ISS The International Space Station is a platform for scientific research that requires one or more of the unusual conditions present in low Earth orbit (for example microgravity, ( cosmic) - radiation and extreme temperatures). The primary field ...


References


External links


ESA article - ESA

EPM homepage - ESA




{{Use British English, date=January 2014 European Space Agency Columbus (ISS module) Science facilities on the International Space Station