Etidocaine, marketed under the trade name Duranest, is an amide-type

local anesthetic A local anesthetic (LA) is a medication that causes absence of pain sensation. In the context of surgery, a local anesthetic creates an absence of pain in a specific location of the body without a loss of consciousness, as opposed to a general an ...

given by

injection Injection or injected may refer to: Science and technology * Injective function, a mathematical function mapping distinct arguments to distinct values * Injection (medicine), insertion of liquid into the body with a syringe * Injection, in broadca ...

during

surgical procedures Many Surgery, surgical procedure names can be broken into parts to indicate the meaning. For example, in gastrectomy, "ectomy" is a suffix (linguistics), suffix meaning the removal of a part of the body. "Gastro-" means stomach. Thus, ''gastrectom ...

and

labor and delivery Childbirth, also known as labour and delivery, is the ending of pregnancy where one or more babies exits the internal environment of the mother via vaginal delivery or caesarean section. In 2019, there were about 140.11 million births globall ...

. Etidocaine has a long duration of activity, and the main disadvantage of using during dentistry is increased bleeding during surgery.

Synthesis

The amide reaction between 2,6-xylidine (1) and 2-bromobutyryl chloride 2118-12-3(2) gives 2-Bromo-N-(2,6-Dimethylphenyl)Butanamide 3984-81-9(3). Alkylation with N-Ethylpropylamine 0193-20-8(4) gives ''Etidocaine'' (5).

References

External links

Duranest
(RxList) Local anesthetics Anilides {{nervous-system-drug-stub