Ernst Witebsky, also Ernest Witebsky (3 September 1901 in
Frankfurt am Main – 7 December 1969) was a German-American immunologist.
Early life and education
Ernst Witebsky was born in
Frankfurt am Main.
From 1920 to 1926 Witebsky studied medicine at the
University of Frankfurt and the
University of Heidelberg.
Career
After graduating from medical school in 1925 he worked with
Hans Sachs at Heidelberg primarily on brain and organ tissue, as well as blood group antigens.
In 1933, he left Germany for Switzerland as a result of
Nazi pressure, and in 1935 joined the Medical School of the
University at Buffalo.
In the 1950s he had begun studying antigens specific to a single organ, in the case of the thyroid gland, the antigen was thyroglobulin. He was a mentor to
Noel Rose
Noel R. Rose (December 3, 1927 – July 30, 2020), was an American immunologist, pathologist, and molecular microbiologist. He is widely known for pioneering autoimmunity during the 1950s and made several contributions to the field of autoimmunity, ...
in this research endeavor to prepare thyroglobulin from rabbits.
In 1967 the State University of New York created The Center for Immunology in Buffalo and appointed him as its first director.
Achievements
Witebsky helped develop procedures for the isolation and partial characterization of A and B blood antigens. He also began the practice of neutralization of certain antibodies in the blood of universal blood donors.
In 1957 he co-authored a paper the "Witebsky's postulates" which determined whether a disease entity could be regarded as an
autoimmune disease
An autoimmune disease is a condition arising from an abnormal immune response to a functioning body part. At least 80 types of autoimmune diseases have been identified, with some evidence suggesting that there may be more than 100 types. Nearly a ...
:
* Direct demonstration of free circulating antibodies active at body temperature.
* Recognition of the specific antigen (for this antibody).
* Production of antibodies against same antigen in experimental animals.
* Experimental animal demonstrates same tissue changes in human.
In 1993, the Postulates were revised based on direct evidence from transfer of pathogenic antibody or pathogenic T-cells, indirect evidence based on reproduction of the autoimmune disease in experimental animals and circumstantial evidence from clinical clues.:
* Auto-antibodies detectable in all cases of disease.
* Experimentally reproducible by immunization with antigen.
* Experimental disease must show immunopathological lesions that parallel those in the natural disease.
* Transferable by serum or lymphoid cells.
In 1959 Witebsky received the Karl Landsteiner Award for his work with blood antibodies.
In 2019, Witebsky was posthumously honored alongside his mentee, Noel Rose, with a
Golden Goose Award for their work on autoimmune disease.
References
Further reading
* National Cyclopaedia of American Biography (1975) "Witebsky, Ernest (1901-1969)" ''The National Cyclopaedia of American Biography: Volume 56'' James T. White & Co., New York;
* Marquis Who's Who (1973) "Witebsky, Ernest (1901-1969)" ''Who Was Who in America, Volume 5, 1969-1973'', Marquis Who's Who, Chicago;
*
Milgrom, Felix (June 1970
"Obituary:Ernest Witebsky" ''Blood'' 35(6): pp. 869-870
External links
Witebsky Center for Microbial Pathogenesis and Immunology
American immunologists
1901 births
1969 deaths
20th-century German physicians
German emigrants to the United States
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