The Emerging Pathogens Institute (EPI) is an interdisciplinary research institution associated with the

University of Florida The University of Florida (Florida or UF) is a public land-grant research university in Gainesville, Florida. It is a senior member of the State University System of Florida, traces its origins to 1853, and has operated continuously on its ...

. The institute focuses on fusing key disciplines to develop outreach, education and research capabilities designed to preserve the region's health and economy, as well as to prevent or contain new and re-emerging diseases. Researchers within the institute work in more than 30 different countries around the world, with over 250 affiliated faculty members stemming from 11 University of Florida colleges, centers and institutes. The 90,000-square-foot building includes laboratories and collaborative space for

bioinformatics Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...

and

mathematical modeling A mathematical model is a description of a system using mathematical concepts and language. The process of developing a mathematical model is termed mathematical modeling. Mathematical models are used in the natural sciences (such as physics, b ...

History

The idea of this institute was first created by the University of Florida faculty and researchers, prompted by the recognition of a need for a facility that could drive pathogen-related research in Florida. Funding for the EPI was provided by the

Florida State Legislature The Florida Legislature is the legislature of the U.S. State of Florida. It is organized as a bicameral body composed of an upper chamber, the Senate, and a lower chamber, the House of Representatives. Article III, Section 1 of the Florida Const ...

in 2006. In 2007, Dr. J. Glenn Morris was recruited from the

University of Maryland, Baltimore The University of Maryland, Baltimore (UMB) is a public university in Baltimore, Maryland. Founded in 1807, it comprises some of the oldest professional schools of dentistry, law, medicine, pharmacy, social work and nursing in the United States ...

to serve as the founding director of the EPI. Construction on a new, dedicated 90,000-square-foot research facility was completed in 2009. The structure houses the institute and numerous top researchers, as well as the Southeastern National Tuberculosis Center (SNTC), the Southern HIV and Alcohol Research Consortium (SHARC) and one of the CDC Centers of Excellence in Vector-borne Diseases. In March 2009, the institute received a substantial grant from the

Bill and Melinda Gates Foundation The Bill & Melinda Gates Foundation (BMGF), a merging of the William H. Gates Foundation and the Gates Learning Foundation, is an American private foundation founded by Bill Gates and Melinda French Gates. Based in Seattle, Washington, it was ...

. This was the first time that the University of Florida has ever received direct funding from this foundation, and the grant was provided to help researchers develop tools to fight

malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or deat ...

Major areas of research

* Vector-Borne Diseases **

Zika Zika fever, also known as Zika virus disease or simply Zika, is an infectious disease caused by the Zika virus. Most cases have no symptoms, but when present they are usually mild and can resemble dengue fever. Symptoms may include fever, red ...

Dengue Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic ...

Chikungunya Chikungunya is an infection caused by the ''Chikungunya virus'' (CHIKV). Symptoms include fever and joint pains. These typically occur two to twelve days after exposure. Other symptoms may include headache, muscle pain, joint swelling, and a ras ...

Malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or deat ...

, Tick-borne diseases * Viral respiratory pathogens **

Coronavirus Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the c ...

Influenza Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptom ...

Tuberculosis Tuberculosis (TB) is an infectious disease usually caused by ''Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in w ...

** Drug-resistant TB ** Non-TB Mycobacterial Disease * Enteric and Foodborne Illnesses **

Cholera Cholera is an infection of the small intestine by some strains of the bacterium '' Vibrio cholerae''. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea that lasts a few days. Vomiting a ...

, diarrheal disease ** Foodborne disease policy and control * Plant Pathogens *

Antibiotic Resistance Antimicrobial resistance (AMR) occurs when microbes evolve mechanisms that protect them from the effects of antimicrobials. All classes of microbes can evolve resistance. Fungi evolve antifungal resistance. Viruses evolve antiviral resistance. ...

/Hospital Infection Control **

MRSA Methicillin-resistant ''Staphylococcus aureus'' (MRSA) is a group of Gram-positive bacteria that are genetically distinct from other strains of ''Staphylococcus aureus''. MRSA is responsible for several difficult-to-treat infections in humans. ...

HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

Zoonoses A zoonosis (; plural zoonoses) or zoonotic disease is an infectious disease of humans caused by a pathogen (an infectious agent, such as a bacterium, virus, parasite or prion) that has jumped from a non-human (usually a vertebrate) to a human. ...

Global research

The Emerging Pathogens Institute channels multidisciplinary programs focused on plant, human and animal

pathogens In biology, a pathogen ( el, πάθος, "suffering", "passion" and , "producer of") in the oldest and broadest sense, is any organism or agent that can produce disease. A pathogen may also be referred to as an infectious agent, or simply a ger ...

, including viral discovery, vector-borne pathogens and, most recently,

coronaviruses Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the c ...

and

pandemic A pandemic () is an epidemic of an infectious disease that has spread across a large region, for instance multiple continents or worldwide, affecting a substantial number of individuals. A widespread endemic disease with a stable number of i ...

preparedness. Publications include papers in top scientific journals, including

Science Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earliest archeological evidence ...

Nature Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are p ...

and

Proceedings of the National Academy of Sciences ''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Scien ...

. Given the speed with which pathogens can move globally, work in the EPI has had a strong international focus, with collaborations in place with investigators in over 50 countries. EPI investigators have been involved in research on various coronavirus species for a number of years. With the onset of the pandemic, the EPI has played a role in population-based studies of

COVID-19 Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease quick ...

, including studies of transmission within schools. Other areas of research have included development of mathematical models predicting spread of the virus in Florida in successive pandemic waves, the critical role of aerosols in transmission of the virus and the transmission of coronaviruses of animal origin into humans.

Directors

2007–Present J. Glenn Morris

References

External links