Sir Edwin Mellor Southern (born 7 June 1938) is an English

Lasker Award The Lasker Awards have been awarded annually since 1945 to living persons who have made major contributions to medical science or who have performed public service on behalf of medicine. They are administered by the Lasker Foundation, which was ...

-winning

molecular biologist Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physic ...

Emeritus ''Emeritus'' (; female: ''emerita'') is an adjective used to designate a retired chair, professor, pastor, bishop, pope, director, president, prime minister, rabbi, emperor, or other person who has been "permitted to retain as an honorary title ...

Professor of Biochemistry at the

University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...

and a fellow of

Trinity College, Oxford (That which you wish to be secret, tell to nobody) , named_for = The Holy Trinity , established = , sister_college = Churchill College, Cambridge , president = Dame Hilary Boulding , location = Broad Street, Oxford OX1 3BH , coordinates ...

. He is most widely known for the invention of the

Southern blot A Southern blot is a method used in molecular biology for detection of a specific DNA sequence in DNA samples. Southern blotting combines transfer of electrophoresis-separated DNA fragments to a filter membrane and subsequent fragment detecti ...

, published in 1975 and now a common laboratory procedure.

Early life and education

Southern was born in

Burnley, Lancashire Burnley () is a town and the administrative centre of the wider Borough of Burnley in Lancashire, England, with a 2001 population of 73,021. It is north of Manchester and east of Preston, at the confluence of the River Calder and River Br ...

and educated at

Burnley Grammar School Burnley Grammar School was latterly, a state-funded selective boys grammar School, situated in Byron Street in Burnley, England. However, during its long history, it moved between a number of sites in the town. History In 1552, on the order of ...

. He has a brother named John Southern and a sister Kay Monie. He went on to read Chemistry at the

University of Manchester The University of Manchester is a public university, public research university in Manchester, England. The main campus is south of Manchester city centre, Manchester City Centre on Wilmslow Road, Oxford Road. The university owns and operates majo ...

(BSc Hons., 1958). He continued as a graduate student (then Demonstrator, 1963) in the Department of Chemistry,

University of Glasgow , image = UofG Coat of Arms.png , image_size = 150px , caption = Coat of arms Flag , latin_name = Universitas Glasguensis , motto = la, Via, Veritas, Vita , ...

, where he was awarded his PhD in 1962.

Career and Research

Southern is also the founder and chairman of Oxford Gene Technology. He is also the founder (in 2000) and chairman of a Scottish charity, The Kirkhouse Trust, which aims to promote education and research in the Natural Sciences, particularly the biological and medical sciences, and the Edina Trust, which was founded to promote science in schools. These charities are financed using royalty income from licensing

microarray A microarray is a multiplex lab-on-a-chip. Its purpose is to simultaneously detect the expression of thousands of genes from a sample (e.g. from a tissue). It is a two-dimensional array on a solid substrate—usually a glass slide or silicon ...

technology.

Southern blot

The

is used for DNA analysis and was routinely used for genetic fingerprinting and paternity testing prior to the development of microsatellite markers for this purpose. The procedure is also frequently used to determine the number of copies of a gene in the genome. The concepts of the Southern blot were used in the development and creation of the modern microarray slide, which is an extensively used experimental tool. The

northern blot The northern blot, or RNA blot,Gilbert, S. F. (2000) Developmental Biology, 6th Ed. Sunderland MA, Sinauer Associates. is a technique used in molecular biology research to study gene expression by detection of RNA (or isolated mRNA) in a sampl ...

western blot The western blot (sometimes called the protein immunoblot), or western blotting, is a widely used analytical technique in molecular biology and immunogenetics to detect specific proteins in a sample of tissue homogenate or extract. Besides detect ...

and eastern blot, related procedures for the analysis of RNA,

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

and

post-translational modification Post-translational modification (PTM) is the covalent and generally enzymatic modification of proteins following protein biosynthesis. This process occurs in the endoplasmic reticulum and the golgi apparatus. Proteins are synthesized by ribo ...

of proteins, respectively, are all puns on Southern's name.

DNA microarray

Southern founded Oxford Gene Technology (OGT) in 1995, a company that developed

DNA microarray A DNA microarray (also commonly known as DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to ...

technology. OGT won a 1999

patent infringement Patent infringement is the commission of a prohibited act with respect to a patented invention without permission from the patent holder. Permission may typically be granted in the form of a license. The definition of patent infringement may v ...

lawsuit against

Affymetrix Affymetrix is now Applied Biosystems, a brand of DNA microarray products sold by Thermo Fisher Scientific that originated with an American biotechnology research and development and manufacturing company of the same name. The Santa Clara, Cali ...

based on his patent holdings in microarray technology.

Awards and honours

In 1990, Southern was one of the winners of the

Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a ...

. In 1998 he was awarded the

Royal Medal The Royal Medal, also known as The Queen's Medal and The King's Medal (depending on the gender of the monarch at the time of the award), is a silver-gilt medal, of which three are awarded each year by the Royal Society, two for "the most important ...

of the

Royal Society of London The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, r ...

. He was made a

Knight Bachelor The title of Knight Bachelor is the basic rank granted to a man who has been knighted by the monarch but not inducted as a member of one of the organised orders of chivalry; it is a part of the British honours system. Knights Bachelor are ...

in the June 2003 Birthday Honours for services to the development of

technologies. In 2005 he was awarded the prestigious

Albert Lasker Award for Clinical Medical Research Lasker-DeBakey Clinical Medical Research Award is one of four annual awards presented by the Lasker Foundation. The Lasker-DeBakey award is given to honor outstanding work for the understanding, diagnosis, prevention, treatment, and cure of diseas ...

, jointly with

Alec Jeffreys Sir Alec John Jeffreys, (born 9 January 1950) is a British geneticist known for developing techniques for genetic fingerprinting and DNA profiling which are now used worldwide in forensic science to assist police detective work and to resolve ...

of the

University of Leicester , mottoeng = So that they may have life , established = , type = public research university , endowment = £20.0 million , budget = £326 million , chancellor = David Willetts , vice_chancellor = Nishan Canagarajah , head_lab ...

for his invention of the Southern blot. In 2005 he was also awarded the

Association of Biomolecular Resource Facilities The Association of Biomolecular Resource Facilities (ABRF) is dedicated to advancing core and research biotechnology laboratories through research, communication, and education. ABRF members include over 2000 scientists representing 340 different ...

Award for outstanding contributions to Biomolecular Technologies. In 2012, he was elected an Honorary Fellow of the

Royal Society of Edinburgh The Royal Society of Edinburgh is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established i ...

. His nomination for the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

reads:

References

{{DEFAULTSORT:Southern, Edwin 1938 births People educated at Burnley Grammar School Members of the European Molecular Biology Organization Living people British molecular biologists Knights Bachelor British biochemists Royal Medal winners Fellows of the Royal Society People from Burnley Whitley Professors of Biochemistry Recipients of the Lasker-DeBakey Clinical Medical Research Award Academics of the University of Edinburgh