Edward Calvin Kendall (March 8, 1886 – May 4, 1972) was an American
chemist
A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe th ...
. In 1950, Kendall was awarded the
Nobel Prize for Physiology or Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according ...
along with Swiss chemist
Tadeusz Reichstein and
Mayo Clinic
The Mayo Clinic () is a nonprofit American academic medical center focused on integrated health care, education, and research. It employs over 4,500 physicians and scientists, along with another 58,400 administrative and allied health staf ...
physician
Philip S. Hench
Philip Showalter Hench (February 28, 1896 – March 30, 1965) was an American physician. Hench, along with his Mayo Clinic co-worker Edward Calvin Kendall and Swiss chemist Tadeus Reichstein was awarded the Nobel Prize for Physiology or Medicine ...
, for their work with the hormones of the adrenal gland. Kendall did not only focus on the adrenal glands, he was also responsible for the isolation of
thyroxine
File:Thyroid_system.svg, upright=1.5, The thyroid system of the thyroid hormones T3 and T4
rect 376 268 820 433 Thyroid-stimulating hormone
rect 411 200 849 266 Thyrotropin-releasing hormone
rect 297 168 502 200 Hypothalamus
rect 66 216 386 25 ...
, a hormone of the
thyroid gland
The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans it is in the neck and consists of two connected lobes. The lower two thirds of the lobes are connected by a thin band of tissue called the thyroid isthmus. The thy ...
and worked with the team that crystallized
glutathione
Glutathione (GSH, ) is an antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by sources such as reactive oxygen species, free radicals, pe ...
and identified its chemical structure.
Kendall was a biochemist at the Graduate School of the
Mayo Foundation at the time of the award. He received his education at
Columbia University
Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
. After retiring from his job with the Mayo Foundation, Kendall joined the faculty at
Princeton University
Princeton University is a private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth as the College of New Jersey, Princeton is the fourth-oldest institution of higher education in the United States and one of the ...
, where he remained until his death in 1972. Kendall Elementary School, in
Norwalk is named for him.
Early life and education
Kendall was born in
South Norwalk, Connecticut in 1886. He attended
Columbia University
Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
, earning a Bachelor of Science degree in 1908, a Master of Science degree in Chemistry in 1909, and a Ph.D. in Chemistry in 1910.
Research career
After obtaining his Ph.D., his first job was in research for Parke, Davis and Company, and his first task was to isolate the hormone associated with the
thyroid gland
The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans it is in the neck and consists of two connected lobes. The lower two thirds of the lobes are connected by a thin band of tissue called the thyroid isthmus. The thy ...
.
He continued this research at St. Luke's Hospital in New York until 1914.
He was appointed Head of the Biochemistry Section in the Graduate School of the
Mayo Foundation, and the following year he was appointed as the Director of the Division of Biochemistry.
Kendall made several notable contributions to biochemistry and medicine. His most notable discovery was the isolation of
thyroxine
File:Thyroid_system.svg, upright=1.5, The thyroid system of the thyroid hormones T3 and T4
rect 376 268 820 433 Thyroid-stimulating hormone
rect 411 200 849 266 Thyrotropin-releasing hormone
rect 297 168 502 200 Hypothalamus
rect 66 216 386 25 ...
, although it was not the work he received the most accolades for.
Along with associates, Kendall was involved with the isolation of
glutathione
Glutathione (GSH, ) is an antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by sources such as reactive oxygen species, free radicals, pe ...
and determining its structure.
He also isolated several steroids from the
adrenal gland
The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol. They are found above the kidneys. Each gland has an outer cortex ...
cortex, one of which was initially called Compound E. Working with
Mayo Clinic
The Mayo Clinic () is a nonprofit American academic medical center focused on integrated health care, education, and research. It employs over 4,500 physicians and scientists, along with another 58,400 administrative and allied health staf ...
physician
Philip Showalter Hench
Philip Showalter Hench (February 28, 1896 – March 30, 1965) was an American physician. Hench, along with his Mayo Clinic co-worker Edward Calvin Kendall and Swiss chemist Tadeus Reichstein was awarded the Nobel Prize for Physiology or Medicine ...
, Compound E was used to treat
rheumatoid arthritis
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are inv ...
. The compound was eventually named
cortisone
Cortisone is a pregnene (21-carbon) steroid hormone. It is a naturally-occurring corticosteroid metabolite that is also used as a pharmaceutical prodrug; it is not synthesized in the adrenal glands. Cortisol is converted by the action of the enz ...
.
In 1950, Kendall and Hench, along with Swiss chemist
Tadeus Reichstein
Tadeusz Reichstein (20 July 1897 – 1 August 1996) was a Polish-Swiss chemist and the Nobel Prize in Physiology or Medicine laureate (1950), which was awarded for his work on the isolation of cortisone.
Early life
Reichstein was born into a Po ...
were awarded the 1950
Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accordi ...
for "their discoveries relating to the hormones of the adrenal cortex, their structure and biological effects."
His Nobel lecture focused on the basic research that led to his award, and was titled "The Development of Cortisone As a Therapeutic Agent."
As of the 2010 awards, Kendall and Hench were the only Nobel Laureates to be affiliated with Mayo Clinic.
Kendall's career at Mayo ended in 1951, when he reached mandatory retirement age. He moved on to
Princeton University
Princeton University is a private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth as the College of New Jersey, Princeton is the fourth-oldest institution of higher education in the United States and one of the ...
, where he was a Visiting Professor in the Department of Biochemistry.
He remained affiliated with Princeton until his death in 1972.
In addition to the Nobel Prize, Kendall received other major awards including the
Lasker Award
The Lasker Awards have been awarded annually since 1945 to living persons who have made major contributions to medical science or who have performed public service on behalf of medicine. They are administered by the Lasker Foundation, which was ...
, the
Passano Foundation
The Passano Foundation, established in 1945, provides an annual award to a research scientist whose work – done in the United States – is thought to have immediate practical benefits. Many Passano laureates have subsequently won the Nobel Priz ...
Award and the
Cameron Prize for Therapeutics of the University of Edinburgh
The Cameron Prize for Therapeutics of the University of Edinburgh is awarded by the College of Medicine and Veterinary Medicine to a person who has made any highly important and valuable addition to Practical Therapeutics in the previous five ye ...
.
Kendall received the Golden Plate Award of the
American Academy of Achievement
The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet ...
in 1966.
He was awarded honorary doctorates from the
University of Cincinnati
The University of Cincinnati (UC or Cincinnati) is a public research university in Cincinnati, Ohio. Founded in 1819 as Cincinnati College, it is the oldest institution of higher education in Cincinnati and has an annual enrollment of over 44,0 ...
,
Western Reserve University
Western may refer to:
Places
*Western, Nebraska, a village in the US
*Western, New York, a town in the US
* Western Creek, Tasmania, a locality in Australia
*Western Junction, Tasmania, a locality in Australia
*Western world, countries that i ...
,
Williams College
Williams College is a private liberal arts college in Williamstown, Massachusetts. It was established as a men's college in 1793 with funds from the estate of Ephraim Williams, a colonist from the Province of Massachusetts Bay who was kille ...
,
Yale University
Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the w ...
,
Columbia University
Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
,
National University of Ireland
The National University of Ireland (NUI) ( ga, Ollscoil na hÉireann) is a federal university system of ''constituent universities'' (previously called '' constituent colleges'') and ''recognised colleges'' set up under the Irish Universit ...
, and
Gustavus Adolphus College
Gustavus Adolphus College ( ) is a private liberal arts college in St. Peter, Minnesota. It was founded in 1862 by Swedish Americans led by Eric Norelius and is affiliated with the Evangelical Lutheran Church in America. Gustavus gets its name ...
.
Family life
Kendall married Rebecca Kennedy in 1915, and they had four children.
He died in 1972 in
Princeton, New Jersey
Princeton is a municipality with a borough form of government in Mercer County, in the U.S. state of New Jersey. It was established on January 1, 2013, through the consolidation of the Borough of Princeton and Princeton Township, both of w ...
.
and his wife died in 1973.
References
External links
Edward Calvin Kendall Biography*
*
*
{{DEFAULTSORT:Kendall, Edward Calvin
1886 births
1972 deaths
20th-century American chemists
Columbia School of Engineering and Applied Science alumni
Columbia Graduate School of Arts and Sciences alumni
Nobel laureates in Physiology or Medicine
American Nobel laureates
Mayo Clinic people
People from Norwalk, Connecticut
Recipients of the Lasker-DeBakey Clinical Medical Research Award
Members of the United States National Academy of Sciences