Evelyn M. Anderson (March 20, 1899 – June 8, 1985) was an American

physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...

and

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological che ...

, most known for her co-discovery of

adrenocorticotropic hormone Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. It is also used as a medication and diagnostic agent. ACTH is an important ...

(adreno-cortical thyroid hormone or ACTH) in 1934.

Background

Evelyn Anderson was born in

Willmar, Minnesota Willmar is a city in, and the county seat of, Kandiyohi County, Minnesota, United States. The population was 21,015 at the 2020 census. History Agricultural expansion and the establishment of Willmar as a division point on the Great Northern ...

, to Swedish immigrants parents. She attended

Carleton College Carleton College ( ) is a private liberal arts college in Northfield, Minnesota. Founded in 1866, it had 2,105 undergraduate students and 269 faculty members in fall 2016. The 200-acre main campus is between Northfield and the 800-acre Cowlin ...

Northfield, Minnesota Northfield is a city in Dakota and Rice counties in the State of Minnesota. It is mostly in Rice County, with a small portion in Dakota County. The population was 20,790 at the 2020 census. History Northfield was platted in 1856 by John W. ...

, where she obtained her bachelor's. In 1928, she gained her M.D. from the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...

, School of Medicine. During her time at Berkeley, her research culminated into two papers about

vitamin A Vitamin A is a fat-soluble vitamin and an essential nutrient for humans. It is a group of organic compounds that includes retinol, retinal (also known as retinaldehyde), retinoic acid, and several provitamin A carotenoids (most notably ...

and

nutrition Nutrition is the biochemical and physiological process by which an organism uses food to support its life. It provides organisms with nutrients, which can be metabolized to create energy and chemical structures. Failure to obtain sufficien ...

. She continued on to receive her Ph.D. in

biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology ...

from the

University of Montreal A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase ''universitas magistrorum et scholarium'', which ...

in 1934. While working on her dissertation, Anderson co-discovered ACTH with

James Bertram Collip James Bertram Collip (November 20, 1892 – June 19, 1965) was a Canadian biochemist who was part of the Toronto group which isolated insulin. He served as the Chair of the Department of Biochemistry at McGill University from 1928–1941 a ...

and David Landsborough Thomson. In a paper published in 1933, she explained its function in the body. In 1935 she published another paper with Collip on the discovery of an anti-thyroid hormone which greatly contributed to the general knowledge and understanding of anti-hormones.

Career

Anderson returned to the University of California to instruct and became an associate professor of medicine in 1946, while continuing her research on hormone related diseases. Most notably she discovered with her husband Webb E. Haymaker that

Cushing's disease Cushing's disease is one cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercortisolism). This is most often as a result of a pituitary adenoma (s ...

is caused by hyper function of the

adrenal cortex The adrenal cortex is the outer region and also the largest part of an adrenal gland. It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. Each zone is responsible for producing specific hormones. It ...

. Anderson also worked with

Joseph Abraham Long Joseph is a common male given name, derived from the Hebrew Yosef (יוֹסֵף). "Joseph" is used, along with "Josef", mostly in English, French and partially German languages. This spelling is also found as a variant in the languages of the mo ...

, professor of embryology, to develop an apparatus to study the secretions of insulin from the pancreas in a rat model. This model and technique were later used with an immunochemical assay for human

insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabol ...

. In 1946, Anderson received an award from the

John Simon Guggenheim Memorial Foundation The John Simon Guggenheim Memorial Foundation was founded in 1925 by Olga and Simon Guggenheim in memory of their son, who died on April 26, 1922. The organization awards Guggenheim Fellowships to professionals who have demonstrated exceptional ...

to work with Phillip Bard, professor and director of the Department of Physiology at

Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hemisphere. It consiste ...

. She then moved to the National Institute of Arthritis and Metabolic Diseases (NIAMD) at the

National Institute of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

where she became the chief of Secretion on

Endocrinology Endocrinology (from ''endocrine'' + '' -ology'') is a branch of biology Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field ...

(1947-1962). She was Vice President and program chairman of the

Endocrine Society The Endocrine Society is a professional, international medical organization in the field of endocrinology and metabolism, founded in 1916 as The Association for the Study of Internal Secretions. The official name of the organization was changed ...

(1951-1952). Anderson became a visiting Professor of Physiology at

Howard University Howard University (Howard) is a Private university, private, University charter#Federal, federally chartered historically black research university in Washington, D.C. It is Carnegie Classification of Institutions of Higher Education, classifie ...

in 1955, where her research focused on hypothalamic regulation of

metabolism Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run c ...

. In 1962 she returned to California where she became head of

neuroendocrinology Neuroendocrinology is the branch of biology (specifically of physiology) which studies the interaction between the nervous system and the endocrine system; i.e. how the brain regulates the hormonal activity in the body. The nervous and endocrine ...

NASA The National Aeronautics and Space Administration (NASA ) is an independent agency of the US federal government responsible for the civil space program, aeronautics research, and space research. NASA was established in 1958, succeedi ...

Ames Research Center The Ames Research Center (ARC), also known as NASA Ames, is a major NASA research center at Moffett Federal Airfield in California's Silicon Valley. It was founded in 1939 as the second National Advisory Committee for Aeronautics (NACA) labora ...

(1962-1969). She retired from this position in 1969. During the course of her career, she published over one hundred research papers.

Personal life

Anderson was married in 1936 to noted neurologist Webb Edward Haymaker, M.D. (1902–1984) with whom she had three children and eight grandchildren.

Award and honors

* John Simon Guggenheim Memorial Foundation Award (1946) * Honorary doctorate from

(1954) *Honorary doctorate from the

Women's Medical College of Pennsylvania A woman is an adult female human. Prior to adulthood, a female human is referred to as a girl (a female child or adolescent). The plural ''women'' is sometimes used in certain phrases such as "women's rights" to denote female humans regardle ...

(1961) * Federal Women's Award recipient (1964)

References

{{DEFAULTSORT:Anderson, Evelyn 1899 births 1985 deaths Carleton College alumni University of California, Berkeley alumni Université de Montréal alumni American women biochemists American physiologists Women physiologists University of California, Berkeley faculty Howard University faculty American people of Swedish descent 20th-century American women 20th-century American people American women academics