Eukaryotic elongation factor 2 is a
protein that in humans is encoded by the ''EEF2''
gene. It is the archaeal and eukaryotic counterpart of bacterial
EF-G.
This gene encodes a member of the
GTP-binding translation
elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the ribosome. This protein is completely inactivated by
EF-2 kinase phosphorylation.
aEF2/eEF2 found in most archaea and eukaryotes, including humans, contains a post translationally modified histidine
diphthamide
Diphthamide is a post-translationally modified histidine amino acid found in archaeal and eukaryotic elongation factor 2 (eEF-2).
Structure
Diphthamide is proposed to be a 2- -carboxyamido-3-(trimethylammonio)propylistidine. Though this structur ...
.
[ It is the target of diphtheria toxin (from '']Corynebacterium diphtheriae
''Corynebacterium diphtheriae'' is the pathogenic bacterium that causes diphtheria. It is also known as the Klebs–Löffler bacillus, because it was discovered in 1884 by German bacteriologists Edwin Klebs (1834–1912) and Friedrich Löffl ...
''), and exotoxin A (from '' Pseudomonas aeruginosa'').
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
External links
*
{{gene-19-stub