Etidocaine, marketed under the trade name Duranest, is an amide-type
local anesthetic
A local anesthetic (LA) is a medication that causes absence of pain sensation. In the context of surgery, a local anesthetic creates an absence of pain in a specific location of the body without a loss of consciousness, as opposed to a general a ...
given by
injection
Injection or injected may refer to:
Science and technology
* Injective function, a mathematical function mapping distinct arguments to distinct values
* Injection (medicine), insertion of liquid into the body with a syringe
* Injection, in broadca ...
during
surgical procedures
Many surgical procedure names can be broken into parts to indicate the meaning. For example, in gastrectomy, "ectomy" is a suffix meaning the removal of a part of the body. "Gastro-" means stomach. Thus, ''gastrectomy'' refers to the surgical remo ...
and
labor and delivery
Childbirth, also known as labour and delivery, is the ending of pregnancy where one or more babies exits the internal environment of the mother via vaginal delivery or caesarean section. In 2019, there were about 140.11 million births globall ...
. Etidocaine has a long duration of activity, and the main disadvantage of using during dentistry is increased bleeding during surgery.
Synthesis
![Etidocaine synthesis](https://upload.wikimedia.org/wikipedia/commons/a/a3/Etidocaine_synthesis.svg)
The amide reaction between
2,6-xylidine (1) and 2-bromobutyryl chloride
2118-12-3(2) gives 2-Bromo-N-(2,6-Dimethylphenyl)Butanamide
3984-81-9(3). Alkylation with N-Ethylpropylamine
0193-20-8(4) gives ''Etidocaine'' (5).
References
External links
Duranest(RxList)
Local anesthetics
Anilides
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