Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an
enzyme that in humans is encoded by the ''MAPK7''
gene.
Function
MAPK7 is a member of the
MAP kinase
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses ...
family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (
MAP2K5
Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the ''MAP2K5'' gene.
Function
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase famil ...
/
MEK5). It is involved in the downstream signaling processes of various receptor molecules including
receptor tyrosine kinases, and
G protein-coupled receptors. In response to extracellular signals, this kinase translocates to the cell nucleus, where it regulates gene expression by
phosphorylating
In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, whi ...
, and activating different
transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
MAPK7 is also critical for cardiovascular development
and is essential for
endothelial cell function.
Interactions
MAPK7 has been shown to
interact with:
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C-Raf,
*
Gap junction protein, alpha 1
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MAP2K5
Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the ''MAP2K5'' gene.
Function
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase famil ...
,
*
MEF2C,
*
MEF2D,
[
* PTPRR,]SGK
Serine/threonine-protein kinases SGK represent a kinase subfamily with orthologs found across animal clades and in yeast (comparTreefam family TF320906. In most vertebrates, including humans, there are three isoforms encoded by the genes ''SGK1' ...
,
References
Further reading
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External links
MAP Kinase Resource
.
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EC 2.7.11