Endothelin converting enzyme 1, also known as ECE1, is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
which in humans is encoded by the ''ECE1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (
EDN1
Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor peptide produced by vascular endothelial cells. The protein encoded by this gene ''EDN1'' is proteolytically processed to release endothelin 1. Endotheli ...
), -2 (
EDN2), and -3 (
EDN3
Endothelin-3 is a protein that in humans is encoded by the ''EDN3'' gene.
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions ...
) to biologically active peptides.
References
Further reading
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