Endodeoxyribonuclease are both
endonuclease
Endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain. Some, such as deoxyribonuclease I, cut DNA relatively nonspecifically (without regard to sequence), while many, typically called restriction endonucleases ...
s and
deoxyribonuclease Deoxyribonuclease (DNase, for short) refers to a group of glycoprotein endonucleases which are enzymes that catalyze the hydrolytic cleavage of phosphodiester linkages in the DNA backbone, thus degrading DNA. The role of the DNase enzyme in cells ...
s. They
catalyze
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
cleavage of the
phosphodiester bond
In chemistry, a phosphodiester bond occurs when exactly two of the hydroxyl groups () in phosphoric acid react with hydroxyl groups on other molecules to form two ester bonds. The "bond" involves this linkage . Discussion of phosphodiesters is ...
s in
DNA. They are classified with
EC numbers 3.1.21 through 3.1.25.
Examples include:
*
DNA restriction enzymes
*
micrococcal nuclease
Micrococcal nuclease (, ''S7 Nuclease'', ''MNase'', ''spleen endonuclease'', ''thermonuclease'', ''nuclease T'', ''micrococcal endonuclease'', ''nuclease T, ''staphylococcal nuclease'', ''spleen phosphodiesterase'', ''Staphylococcus aureus nucle ...
See also
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Ribonuclease
Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the ...
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UvrABC endonuclease
UvrABC endonuclease is a multienzyme complex in bacteria involved in DNA repair by nucleotide excision repair, and it is, therefore, sometimes called an excinuclease. This UvrABC repair process, sometimes called the short-patch process, involves ...
External links
*
EC 3.1
Deoxyribonucleases
{{hydrolase-stub