Empalme (Spanish: "junction", "splice", "union") may refer to
;Places
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Empalme, Sonora Empalme is a city surrounded by a municipality located on the south-central coast of the Mexican state of Sonora. According to the 2005 census the population of the city was 40,630 inhabitants, while the municipality, which has an area of 708.53& ...
, city in northwestern Mexico
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Empalme Villa Constitución, town in the Argentine province of Santa Fe
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El Empalme, town in the Ecuadorian province of Guayas
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Empalme Escobedo, in the Mexican state of Guanajuato
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Empalme Nicolich, in Uruguay
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Empalme Olmos, in Uruguay
;Other
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Empalme (food), tortilla sandwich originating in the Mexican state of Nuevo León
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Empalme (Madrid Metro), station on Line 5 of the
Madrid Metro
The Madrid Metro (Spanish: ''Metro de Madrid'') is a rapid transit system serving the city of Madrid, capital of Spain. The system is the 14th longest rapid transit system in the world, with a total length of 293 km (182 mi). Its gro ...
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