Emil Paleček
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Emil Paleček (3 October 1930 – 30 October 2018) was a Czech
biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...
, who researched how DNA can be used to diagnose genetic diseases. Paleček discovered that nucleic acids could be analysed by electrochemical research, contradicting previous assumptions from the 1950s that DNA molecules were too large to be affected by electrochemistry.


Personal life

Paleček was brought up by his mother, as his father died in a Nazi concentration camp. Aged 13, he went to work as an apprentice at the Bank of Slavia.


Career

Paleček had a specific interest in the fact that most proteins contain sugar, as he believed that analysis of this could lead to better diagnosis of health and illnesses. In particular, he believed that testing glycoproteins could detect early-stage
cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...
. In 1959, Paleček received a
PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * ''Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. albu ...
in
biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
from
Masaryk University Masaryk University (MU) ( cs, Masarykova univerzita; la, Universitas Masarykiana Brunensis) is the second largest university in the Czech Republic, a member of the Compostela Group and the Utrecht Network. Founded in 1919 in Brno as the seco ...
in
Brno Brno ( , ; german: Brünn ) is a city in the South Moravian Region of the Czech Republic. Located at the confluence of the Svitava and Svratka rivers, Brno has about 380,000 inhabitants, making it the second-largest city in the Czech Republic ...
,
Czechoslovakia , rue, Чеськословеньско, , yi, טשעכאסלאוואקיי, , common_name = Czechoslovakia , life_span = 1918–19391945–1992 , p1 = Austria-Hungary , image_p1 ...
(now in the
Czech Republic The Czech Republic, or simply Czechia, is a landlocked country in Central Europe. Historically known as Bohemia, it is bordered by Austria to the south, Germany to the west, Poland to the northeast, and Slovakia to the southeast. The ...
). During the 1960s, Paleček worked at the Biophysical Institute of the Academy of Sciences in Brno. His first work there was investigating DNA damage caused by radiation. Paleček later worked with the Masaryk Memorial Cancer Institute, part of Masaryk University. In 1960, Paleček discovered that nucleic acids could be analysed through electrochemical research, which allowed him to explore how DNA can be used to diagnose genetic diseases. His discovery contradicted previous assumptions from the 1950s that DNA molecules were too large to be analysed by electrochemical research. It took the scientific world 30 years to understand the importance of his findings, although the method began to be commonly used in the 1990s. In the 1960s, Paleček spent a year doing research at
Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...
in the
United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...
. Paleček was allowed to travel to the United States as he was not a member of the Communist Party of Czechoslovakia. In his last month at Harvard University, Paleček's experiments were demonstrated. They were later cited in many biophysics and
molecular biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...
textbooks. During his life, Paleček authored over 300 scientific works, making him one of the most respected scientists in the Czech Republic. In 1989, Paleček became a member of the
Czechoslovak Academy of Sciences The Czechoslovak Academy of Sciences (Czech: ''Československá akademie věd'', Slovak: ''Česko-slovenská akadémia vied'') was established in 1953 to be the scientific center for Czechoslovakia. It was succeeded by the Czech Academy of Science ...
. From 1993 to 1997, he was a member of the Czech Academy of Sciences. In 1994, Paleček was one of the founding members of the
Learned Society of the Czech Republic Learning is the process of acquiring new understanding, knowledge, behaviors, skills, values, attitudes, and preferences. The ability to learn is possessed by humans, animals, and some machines; there is also evidence for some kind of learn ...
. In 2003, Paleček was the speaker for one of the
Mendel Lectures The Mendel Lectures is a series of lectures given by the world's top scientists in genetics, molecular biology, biochemistry, microbiology, medicine and related areas which has been held in the refectory of the Augustian Abbey of St. Thomas in Brno ...
. In 2009, the Emil Paleček award, was setup by the President of the Czech Academy of Sciences. Paleček was still working on the Saturday before his death.


Awards

In 1961, Paleček was awarded the Jaroslav Heyrovský award for best young scientist. In 2011, he received the Education Minister's award. In 2014, Paleček was awarded the (Czech Head) award. In 2017, he was one of seven Czech scientists awarded the Cenu Neuron (Neuron Prize) for their contributions to science.


Death

Paleček became ill after having a
stroke A stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functionin ...
whilst swimming. He died two days later on 30 October 2018. His death was announced by fellow scientist Eduard Kejnovsky, who worked as Paleček's public relations officer.


References

{{DEFAULTSORT:Palecek, Emil Czech biochemists Masaryk University alumni Czechoslovak chemists 1930 births 2018 deaths People from Brno Academic staff of Masaryk University