''Eleutherococcus senticosus'' is a species of small, woody
shrub
A shrub (often also called a bush) is a small-to-medium-sized perennial woody plant. Unlike herbaceous plants, shrubs have persistent woody stems above the ground. Shrubs can be either deciduous or evergreen. They are distinguished from trees ...
in the family
Araliaceae
The Araliaceae are a family of flowering plants composed of about 43 genera and around 1500 species consisting of primarily woody plants and some herbaceous plants. The morphology of Araliaceae varies widely, but it is predominantly distinguisha ...
native to
Northeastern Asia
Northeast Asia or Northeastern Asia is a geographical subregion of Asia; its northeastern landmass and islands are bounded by the Pacific Ocean.
The term Northeast Asia was popularized during the 1930s by American historian and political scienti ...
.
It may be colloquially called devil's bush, Siberian ginseng, eleuthero, ''ciwujia'', ''Devil's shrub'', ''shigoka'', ''touch-me-not'', ''wild pepper'', or ''kan jang''. ''E. senticosus'' has a history of use in folklore and traditional Chinese medicine
Traditional Chinese medicine (TCM) is an alternative medical practice drawn from traditional medicine in China. It has been described as "fraught with pseudoscience", with the majority of its treatments having no logical mechanism of action ...
. Root extract
An extract is a substance made by extracting a part of a raw material, often by using a solvent such as ethanol, oil or water. Extracts may be sold as tinctures, absolutes or in powder form.
The aromatic principles of many spices, nuts, h ...
s of ''E. senticosus'' are sold as a dietary supplement
A dietary supplement is a manufactured product intended to supplement one's diet by taking a pill, capsule, tablet, powder, or liquid. A supplement can provide nutrients either extracted from food sources or that are synthetic in order ...
or cosmetic
Cosmetic may refer to:
*Cosmetics, or make-up, substances to enhance the beauty of the human body, apart from simple cleaning
*Cosmetic, an adjective describing beauty, aesthetics, or appearance, especially concerning the human body
*Cosmetic, a t ...
, usually under the name ''Siberian ginseng''.[
]
Etymology
The scientific name (genus
Genus ( plural genera ) is a taxonomic rank used in the biological classification of extant taxon, living and fossil organisms as well as Virus classification#ICTV classification, viruses. In the hierarchy of biological classification, genus com ...
), ''Eleutherococcus'' (from Greek) means "free-berried," and ''senticosus'', (from Latin) means ''sentis'' (thorn-bush, briar), an adjective meaning "thorny" or "full of briers or thorns." It is not the same plant as American ginseng
American ginseng (''Panax quinquefolius'') is a herbaceous perennial plant in the ivy family, commonly used as an herb in traditional Chinese medicine. It is native to eastern North America, though it is also cultivated in China. Since the 18th ...
(''Panax quinquefolius'') or Asian ginseng
''Panax ginseng'', ginseng, also known as Asian ginseng, Chinese ginseng, or Korean ginseng, is a species of plant whose root is the original source of ginseng. It is a perennial plant that grows in the mountains of East Asia. Names
''Panax gi ...
(''Panax ginseng''). It has a diversity of common names across its range of distribution.[
]
Distribution and habitat
The herb grows in mixed and coniferous mountain forests, forming low undergrowth or is found in groups in thickets and edges. ''Eleutherococcus senticosus'' is sometimes found in oak groves at the foot of cliffs, rarely in high forest riparian
A riparian zone or riparian area is the interface between land and a river or stream. Riparian is also the proper nomenclature for one of the terrestrial biomes of the Earth. Plant habitats and communities along the river margins and banks ar ...
woodland. Its native habitat is East Asia, China, Japan, and Russia.[ ''E. senticosus'' is broadly tolerant of soils, growing in sandy, loamy, and heavy clay soils with acid, neutral, or alkaline chemistry and including soils of low nutritional value. It can tolerate sun or dappled shade and some degree of pollution. ''E. senticosus'' is a ]deciduous
In the fields of horticulture and Botany, the term ''deciduous'' () means "falling off at maturity" and "tending to fall off", in reference to trees and shrubs that seasonally shed leaves, usually in the autumn; to the shedding of petals, aft ...
shrub growing to at a slow rate. It is hardy to zone 3. It flowers in July in most habitats. The flowers are hermaphroditic
In reproductive biology, a hermaphrodite () is an organism that has both kinds of reproductive organs and can produce both gametes associated with male and female sexes.
Many taxonomic groups of animals (mostly invertebrates) do not have separ ...
and are pollinated by insects.
Extract and chemical constituents
Roots of ''E. senticosus'' are cylindrical, up to in diameter, straight or branched, dark brown, and have a smooth surface with bark fixed closely to the xylem
Xylem is one of the two types of transport tissue in vascular plants, the other being phloem. The basic function of xylem is to transport water from roots to stems and leaves, but it also transports nutrients. The word ''xylem'' is derived from ...
.[ The derived ]extract
An extract is a substance made by extracting a part of a raw material, often by using a solvent such as ethanol, oil or water. Extracts may be sold as tinctures, absolutes or in powder form.
The aromatic principles of many spices, nuts, h ...
from the roots has been characterized for its major constituents, including lignan
The lignans are a large group of low molecular weight polyphenols found in plants, particularly seeds, whole grains, and vegetables. The name derives from the Latin word for "wood". Lignans are precursors to phytoestrogens. They may play a role ...
s, sesamin
Sesamin is a lignan isolated from the bark of ''Fagara'' plants and from sesame oil. It has been used as a dietary fat-reduction supplement. Its major metabolite is enterolactone, which has an elimination half life of less than 6 hours. Sesamin an ...
(eleutheroside
Eleutherosides are a diverse group of chemical compounds that were isolated from roots of the herb ''Eleutherococcus senticosus'' which is commercially offered mostly as extracts. Eleutheroside A is a saponin and sterol glycoside while other eleuth ...
B4), syringaresinol, phenylpropanes, coumarin
Coumarin () or 2''H''-chromen-2-one is an aromatic organic chemical compound with formula . Its molecule can be described as a benzene molecule with two adjacent hydrogen atoms replaced by a lactone-like chain , forming a second six-membered h ...
s, beta-sitosterol
β-sitosterol (beta-sitosterol) is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol. It is a white, waxy powder with a characteristic odor, and is one of the components of the food additive E499 ...
and daucosterol
Daucosterol (eleutheroside A) is a natural phytosterol-like compound. It is the glucoside of β-sitosterol.
References
{{steroid-stub
Sterols
Glucosides
Saponins ...
.[
Berries from ''E. senticosus'' contain diverse ]polyphenol
Polyphenols () are a large family of naturally occurring organic compounds characterized by multiples of phenol units. They are abundant in plants and structurally diverse. Polyphenols include flavonoids, tannic acid, and ellagitannin, some of ...
s, including caffeic acid
Caffeic acid is an organic compound that is classified as a hydroxycinnamic acid. This yellow solid consists of both phenolic and acrylic functional groups. It is found in all plants because it is an intermediate in the biosynthesis of lignin, one ...
, vanillic acid
Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a dihydroxybenzoic acid derivative used as a flavoring agent. It is an oxidized form of vanillin. It is also an intermediate in the production of vanillin from ferulic acid.
Occurrence in natu ...
, ferulic acid
Ferulic acid is a hydroxycinnamic acid, an organic compound with the formula (CH3O)HOC6H3CH=CHCO2H. The name is derived from the genus ''Ferula'', referring to the giant fennel (''Ferula communis''). Classified as a phenolic phytochemical, ferulic ...
, p-coumaric acid, and benzoic acid
Benzoic acid is a white (or colorless) solid organic compound with the formula , whose structure consists of a benzene ring () with a carboxyl () substituent. It is the simplest aromatic carboxylic acid. The name is derived from gum benzoin, wh ...
, with significant content of calcium
Calcium is a chemical element with the symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar to ...
, magnesium
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a shiny gray metal having a low density, low melting point and high chemical reactivity. Like the other alkaline earth metals (group 2 of the periodic ta ...
, and potassium
Potassium is the chemical element with the symbol K (from Neo-Latin ''kalium'') and atomic number19. Potassium is a silvery-white metal that is soft enough to be cut with a knife with little force. Potassium metal reacts rapidly with atmosphe ...
.
Major constituents of essential oil
An essential oil is a concentrated hydrophobic liquid containing volatile (easily evaporated at normal temperatures) chemical compounds from plants. Essential oils are also known as volatile oils, ethereal oils, aetheroleum, or simply as the o ...
from leaves of ''Eleutherococcus senticosus'' include α-bisabolol
Bisabolol, or more formally α-(−)-bisabolol or also known as levomenol, is a natural monocyclic sesquiterpene alcohol. It is a colorless viscous oil that is the primary constituent of the essential oil from German chamomile (''Matricaria recut ...
(26%), β-caryophyllene
Caryophyllene (), more formally (−)-β-caryophyllene, (BCP), is a natural bicyclic sesquiterpene that is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of '' Syzygium aromaticum'' (cloves), the ess ...
(7%), germacrene D
Germacrenes are a class of volatile organic hydrocarbons, specifically, sesquiterpenes. Germacrenes are typically produced in a number of plant species for their antimicrobial and insecticidal properties, though they also play a role as insect ph ...
(7%), β-bisabolene
Bisabolenes are a group of closely related natural chemical compounds which are classified as sesquiterpenes. Bisabolenes are produced from farnesyl pyrophosphate (FPP) and are present in the essential oils of bisabol, and of a wide variety of o ...
(5%), and α-humulene
Humulene, also known as α-humulene or α-caryophyllene, is a naturally occurring monocyclic sesquiterpene (C15H24), containing an 11-membered ring and consisting of 3 isoprene units containing three nonconjugated C=C double bonds, two of them be ...
(4%).
Traditional medicine
Extract
An extract is a substance made by extracting a part of a raw material, often by using a solvent such as ethanol, oil or water. Extracts may be sold as tinctures, absolutes or in powder form.
The aromatic principles of many spices, nuts, h ...
s from the root of ''Eleutherococcus senticosus'', including eleutheroside
Eleutherosides are a diverse group of chemical compounds that were isolated from roots of the herb ''Eleutherococcus senticosus'' which is commercially offered mostly as extracts. Eleutheroside A is a saponin and sterol glycoside while other eleuth ...
s, are promoted in alternative
Alternative or alternate may refer to:
Arts, entertainment and media
* Alternative (''Kamen Rider''), a character in the Japanese TV series ''Kamen Rider Ryuki''
* ''The Alternative'' (film), a 1978 Australian television film
* ''The Alternative ...
and traditional medicine
Traditional medicine (also known as indigenous medicine or folk medicine) comprises medical aspects of traditional knowledge that developed over generations within the folk beliefs of various societies, including indigenous peoples, before the ...
for providing health effects, none of which are supported by clinical evidence. According to the WHO
Who or WHO may refer to:
* Who (pronoun), an interrogative or relative pronoun
* Who?, one of the Five Ws in journalism
* World Health Organization
Arts and entertainment Fictional characters
* Who, a creature in the Dr. Seuss book '' Horton He ...
, only "as a prophylactic and restorative tonic for enhancement of mental and physical capacities in cases of weakness, exhaustion and tiredness, and during convalescence" is backed up by clinical evidence. The plant has been assessed in preliminary research for its potential use as an antimicrobial
An antimicrobial is an agent that kills microorganisms or stops their growth. Antimicrobial medicines can be grouped according to the microorganisms they act primarily against. For example, antibiotics are used against bacteria, and antifungals ar ...
or antistress agent,[ but these studies were of poor quality and there is no scientific confirmation that such effects exist.][
]
Potential for adverse effects
People with high blood pressure, sleep apnea
Sleep apnea, also spelled sleep apnoea, is a sleep disorder in which pauses in breathing or periods of shallow breathing during sleep occur more often than normal. Each pause can last for a few seconds to a few minutes and they happen many times ...
, narcolepsy
Narcolepsy is a long-term neurological disorder that involves a decreased ability to regulate sleep–wake cycles. Symptoms often include periods of excessive daytime sleepiness and brief involuntary sleep episodes. About 70% of those affec ...
, heart disease
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, hea ...
, mental illness, a compromised immune system
The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinte ...
, people in the processes of pregnancy and lactation, and people taking digoxin
Digoxin (better known as Digitalis), sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. Digoxin is on ...
or hexobarbital
Hexobarbital or hexobarbitone, sold both in acid and sodium salt forms as Citopan, Evipan, and Tobinal, is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s and 1950s as an agent for inducing anesthesia for su ...
may have adverse reactions to ''E. senticosus''.[ High doses may cause irritability, confusion, ]insomnia
Insomnia, also known as sleeplessness, is a sleep disorder in which people have trouble sleeping. They may have difficulty falling asleep, or staying asleep as long as desired. Insomnia is typically followed by daytime sleepiness, low energy, ...
, or anxiety.[
]
References
External links
''Eleutherococcus senticosus'' Photos (PlantSystematics.org)
{{Authority control
senticosus
Antidepressants
Herbs
Medicinal plants
Flora of China
Flora of Japan
Flora of Korea
Flora of Siberia