Eleftheria Maratos-Flier is an American endocrinologist, and emerita Professor of Medicine at

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

, best known for her expertise in the pathophysiology and prevention of obesity-related metabolic disorders, and for her discoveries on the neuroendocrine control of feeding behaviour. She is a contributing author to known textbooks and reviews in internal medicine,

endocrinology Endocrinology (from '' endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental event ...

, and

physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...

. Her marriage with professor

Jeffrey Flier Jeffrey Flier is an American physician, endocrinologist, widely cited scientist, ''Higginson Professor of Medicine and Physiology, and Harvard University Distinguished Service Professor'' at Harvard Medical School. He was the 21st Dean of the Facu ...

, was noted by

Forbes ''Forbes'' () is an American business magazine owned by Integrated Whale Media Investments and the Forbes family. Published eight times a year, it features articles on finance, industry, investing, and marketing topics. ''Forbes'' also re ...

as a lasting and productive bond between eminent medical scholars. They have two adult daughters who are also physicians. She is also known as Terry Maratos-Flier.

Education

In 1972, she graduated with a BA in Chemistry from

New York University New York University (NYU) is a private research university in New York City. Chartered in 1831 by the New York State Legislature, NYU was founded by a group of New Yorkers led by then-Secretary of the Treasury Albert Gallatin. In 1832, the ...

, New York, NY. In 1976, she graduated as an MD from the

Mount Sinai School of Medicine The Icahn School of Medicine at Mount Sinai (ISMMS or Mount Sinai), formerly the Mount Sinai School of Medicine, is a private medical school in New York City. It is the academic teaching arm of the Mount Sinai Health System, which manages eigh ...

, New York, NY, followed by internship and residency training in internal medicine at George Washington University Hospital, Washington, DC. In Massachusetts (1978-1981), she pursued further residency training in internal medicine at Beth Israel Hospital, postdoctoral research fellowship at Harvard School of Public Health, and Clinical Fellowship at the

Joslin Diabetes Center Joslin Diabetes Center is the world's largest diabetes research center, diabetes clinic, and provider of diabetes education. It is located in the Longwood Medical and Academic Area in Boston, Massachusetts, United States. Among the Harvard Medica ...

and

Brigham and Women’s Hospital Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two f ...

Career

Since 1982 she has taught at

, becoming a full Professor of Medicine from 2010 to 2018, when she became professor emerita. She has been an associate member of the

Broad Institute The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, Cambridge, Massachusetts, U ...

, and a Principal Investigator of many NIH-funded research grants. She has also been an attending endocrinologist at

Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts is a teaching hospital of Harvard Medical School. It was formed out of the 1996 merger of Beth Israel Hospital (founded in 1916) and New England Deaconess Hospital (founded ...

, where she still provides care for patients with metabolic disease. From 2018, she has been Director, Translational Medicine, at Novartis Institutes of Biomedical Research, Cambridge, MA., recently moving to

Alnylam Alnylam Pharmaceuticals, Inc. is an American biopharmaceutical company focused on the discovery, development and commercialization of RNA interference (RNAi) therapeutics for genetically defined diseases. The company was founded in 2002 and is he ...

to serve as a director of clinical research. She has authored more than 100 peer reviewed manuscripts, most of them studying aspects of obesity and type II diabetes in experimental mouse models, and also in clinical disease. She also authored the obesity chapters of the 20th edition of ''

Harrison's Principles of Internal Medicine ''Harrison's Principles of Internal Medicine'' is an American textbook of internal medicine. First published in 1950, it is in its 21st edition (published in 2022 by McGraw-Hill Professional ) and comes in two volumes. Although it is aimed at a ...

'' (jointly with Jeffrey Flier)'','' and the 14th edition of ''Williams Textbook of Endocrinology.'' In 2016, she contributed a seminal article to the

Annual Review of Physiology The ''Annual Review of Physiology'' is a peer-reviewed academic journal that publishes review articles about physiology. First published in 1939 through a collaboration between the American Physiological Society and Annual Reviews, it was publish ...

on the physiology of Fibroblast Growth Factor 21.

Awards

* 1971 - Undergraduate Award in Analytical Chemistry from the ACS to outstanding undergraduate chemistry students. * 2011 - Saul Horowitz Distinguished Alumni Award, given for outstanding achievements since graduation from the Icahn School of Medicine at Mount Sinai. * 2020 - Roy O. Greep Award for Outstanding Research given by the

Endocrine Society The Endocrine Society is a professional, international medical organization in the field of endocrinology and metabolism, founded in 1916 as The Association for the Study of Internal Secretions. The official name of the organization was changed ...

Selected works

Maratos-Flier's research papers have been cited over 15,600 times. Her most cited papers are: * Qu, Daqing; Ludwig, David S.; Gammeltoft, Steen; Piper, Megan; Pelleymounter, Mary Ann; Cullen, Mary Jane; Mathes, Wendy Foulds; Przypek, Jeanne; Kanarek, Robin; Maratos-Flier, Eleftheria (1996-03-01). "A role for melanin-concentrating hormone in the central regulation of feeding behaviour". ''Nature''. 380 (6571): 243–247. doi:10.1038/380243a0.PMID 8637571. * Ahima, Rexford S.; Prabakaran, Daniel; Mantzoros, Christos; Qu, Daqing; Lowell, Bradford; Maratos-Flier, Eleftheria; Flier, Jeffrey S. (1996-07-01). "Role of leptin in the neuroendocrine response to fasting". ''Nature''. 382 (6588): 250–252. doi:10.1038/382250a0. PMID 8717038. * Badman, Michael K.; Pissios, Pavlos; Kennedy, Adam R.; Koukos, George; Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2007-06-01). "Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States". ''Cell Metabolism''. 5 (6): 426–437. doi:10.1016/j.cmet.2007.05.002. PMID 17550778. * Fisher, ffolliott M.; Kleiner, Sandra; Douris, Nicholas; Fox, Elliott C.; Mepani, Rina J.; Verdeguer, Francisco; Wu, Jun; Kharitonenkov, Alexei; Flier, Jeffrey S.; Maratos-Flier, Eleftheria; Spiegelman, Bruce M. (2012-02-01). "FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis". ''Genes & Development''. 26 (3): 271–281. doi:10.1101/gad.177857.111. PMID 22302939

References

{{DEFAULTSORT:Maratos-Flier, Eleftheria 1951 births Living people American endocrinologists New York University alumni Icahn School of Medicine at Mount Sinai alumni Harvard Medical School faculty