Eleanor Barnes is a British physician at the

John Radcliffe Hospital The John Radcliffe Hospital (informally known as the JR) is a large tertiary teaching hospital in Oxford, England. It forms part of the Oxford University Hospitals NHS Foundation Trust and is named after John Radcliffe, an 18th-century physici ...

and a Professor of Hepatology and Experimental Medicine at the

University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...

. She has studied

hepatitis C Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, a ...

and the development of the development of HCV vaccines. She is a Fellow of the

Academy of Medical Sciences The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society. Its mission is to adv ...

and serves as the lead for

hepatology Hepatology is the branch of medicine that incorporates the study of liver, gallbladder, biliary tree, and pancreas as well as management of their disorders. Although traditionally considered a sub-specialty of gastroenterology, rapid expansion ...

at the

National Institute for Health Research The National Institute for Health and Care Research (NIHR) is the British government’s major funder of clinical, public health, social care and translational research. With a budget of over £1.2 billion in 2020–21, its mission is to "impr ...

(NIHR) Clinical Research Network.

Early life and education

Barnes has said that she was interested in science as a child. She decided to study medicine at university, and eventually trained at

St Bartholomew's Hospital St Bartholomew's Hospital, commonly known as Barts, is a teaching hospital located in the City of London. It was founded in 1123 and is currently run by Barts Health NHS Trust. History Early history Barts was founded in 1123 by Rahere (died ...

. She completed an intercalated bachelor's degree in anthropology and philosophy. After graduating, she worked as a medical resident at the

Royal Free Hospital The Royal Free Hospital (also known simply as the Royal Free) is a major teaching hospital in the Hampstead area of the London Borough of Camden. The hospital is part of the Royal Free London NHS Foundation Trust, which also runs services at Barn ...

, where she decided to specialise in

and

gastroenterology Gastroenterology (from the Greek gastḗr- “belly”, -énteron “intestine”, and -logía "study of") is the branch of medicine focused on the digestive system and its disorders. The digestive system consists of the gastrointestinal tract ...

. Determined to pursue a career in research, Barnes worked unpaid for three months, during which time she obtained data that she used to apply for a fellowship from the Medical Research Council. She was a doctoral researcher at the

University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...

. Her doctoral research considered

T cell A T cell is a type of lymphocyte. T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell r ...

and

dendritic cell Dendritic cells (DCs) are antigen-presenting cells (also known as ''accessory cells'') of the mammalian immune system. Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system. ...

function.

Research and career

Barners' research considers

immunology. She is focused on the translation of laboratory findings to clinical environments. Barnes worked as a Medical Research Council Senior Fellow at the

University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...

, and eventually was appointed lead of herpetology in the

Thames Valley The Thames Valley is an informally-defined sub-region of South East England, centred on the River Thames west of London, with Oxford as a major centre. Its boundaries vary with context. The area is a major tourist destination and economic hub, ...

. She studied why 80% of patients with

get chronic infection. Barnes identified that the nature of the T cell response determines which pathway a patient goes down. This observation led Barnes to develop an T-cell vaccine to prevent hepatitis C infection. The vaccine is based on adenoviral vectors, which host the non-structural proteins of hepatitis C from a genotype 1B strain. There are seven major hepatitis C strains, which presents considerable challenges for the development of vaccines. Barnes was elected Fellow of the

in 2018. During the

COVID-19 pandemic The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The novel virus was first identif ...

, Barnes studied the design, effectiveness and implementation of the

COVID-19 vaccine A COVID19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 ( COVID19). Prior to the COVID19 pandemic, an e ...

. She showed that patients who suffered from

COVID-19 Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was COVID-19 pandemic in Hubei, identified in Wuhan, China, in December ...

were likely to be impacted by liver problems.

Selected publications

* * *

Personal life

Barnes is married with two children.

References

{{DEFAULTSORT:Barnes, Eleanor Fellows of the Academy of Medical Sciences (United Kingdom) British women scientists British women academics Academics of the University of Oxford 20th-century British medical doctors 20th-century British women medical doctors 21st-century British medical doctors NIHR Senior Investigators Hepatitis researchers Year of birth missing (living people) Living people Alumni of the University of Oxford