Ehrlich-Lettre ascites carcinoma (EAC) is also known as Ehrlich cell. It was originally established as an

ascites Ascites is the abnormal build-up of fluid in the abdomen. Technically, it is more than 25 ml of fluid in the peritoneal cavity, although volumes greater than one liter may occur. Symptoms may include increased abdominal size, increased weight, ab ...

tumor in mice.

Ehrlich cell

The tumor was cultured ''

in vivo Studies that are ''in vivo'' (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and ...

'', which became known as the Ehrlich cell. After 1948 Ehrlich cultures spread around research institutes all over the world. The Ehrlich cell became popular because it could be expanded by ''in vivo'' passage. This made it useful for biochemical studies involving large amounts of tissues. It could also be maintained ''

in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology an ...

'' for more carefully controlled studies. Culture techniques in large-scale, mice passage is less attractive, due to the contamination of the tumor with multifarious host inflammatory cells.

Properties

EAC is referred to as undifferentiated

carcinoma Carcinoma is a malignancy that develops from epithelial cells. Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal, mesodermal ...

, and is originally hyper-diploid. The permeability to water is highest at the initiation of the

S phase S phase (Synthesis Phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase. Since accurate duplication of the genome is critical to successful cell division, the processes that occur during ...

and progressively decreases to its lowest value just after

mitosis In cell biology, mitosis () is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Cell division by mitosis gives rise to genetically identical cells in which the total number of chromosomes is mainta ...

. Activation heats for water permeability vary during the cell cycle, ranging from 9–14 kca/mole.

References

External links

* * * {{cite journal, title=Osmotic properties of ehrlich ascites tumor cells during the cell cycle , doi=10.1002/jcp.1040970313, pmid=569663, volume=97, issue = 3, journal=J Cell Physiol, pages=381–96 , last1 = DuPre , first1 = AM , last2 = Hempling , first2 = HG, year = 1978, s2cid=22541255 Cell biology