Econazole is an antifungal medication of the imidazole class. It was patented in 1968, and approved for medical use in 1974.

Medical uses

Econazole is used as a cream to treat skin infections such as athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch. It is also sold in Canada under the brand name Ecostatin as vaginal ovules to treat vaginal

thrush ''The Man from U.N.C.L.E.'' is an American spy fiction television series produced by Metro-Goldwyn-Mayer Television and first broadcast on NBC. The series follows secret agents, played by Robert Vaughn and David McCallum, who work for a secret ...

. Econazole nitrate exhibits strong anti-feeding properties against the keratin-digesting common clothes moth '' Tineola bisselliella''.

Adverse effects

About 3% of patients treated with econazole nitrate cream reported side effects. The most common symptoms were burning, itching, redness ( erythema), and one outbreak of a pruritic rash.

Synthesis

Imidazoles devoid of the nitro group no longer have any antiprotozoal activity, however, such drugs are effective

antifungal agents An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as c ...

Alkylation of imidazole (2) with bromoketone (1) prepared from ''o,p''-dichloro acetophenone affords the displacement product (3). Reduction of the ketone with sodium borohydride gives the corresponding alcohol (4). Alkylation of the

alkoxide In chemistry, an alkoxide is the conjugate base of an alcohol and therefore consists of an organic group bonded to a negatively charged oxygen atom. They are written as , where R is the organic substituent. Alkoxides are strong bases and, whe ...

from that alcohol with ''p''-chlorobenzyl chloride leads to econazole (5); alkylation with ''o,p''-dichlorobenzyl chloride gives miconazole.

Society and culture

Brand names

It is sold under the brand names Spectrazole ( United States) and Ecostatin ( Canada), among others. It is a component of Pevisone, Ecoderm-TAProduct descriptions
at REPHCO Pharmaceuticals Limited, Bangladesh. Retrieved June 2012 and ECOSONE (

econazole/triamcinolone Econazole/triamcinolone is a combination drug, consisting of econazole (an imidazole antifungal) and triamcinolone (a group III topical steroid). It is used as a topical cream against fungal skin infections, including '' Trichophyton men ...

References

External links

* 21-Hydroxylase inhibitors Aromatase inhibitors Chloroarenes CYP3A4 inhibitors CYP17A1 inhibitors Phenylethanolamine ethers Imidazole antifungals Lanosterol 14α-demethylase inhibitors General cytochrome P450 inhibitors {{antiinfective-drug-stub