''Echis carinatus'', known as the saw-scaled viper,Mallow D, Ludwig D, Nilson G (2003). ''True Vipers: Natural History and Toxinology of Old World Vipers''. Malabar, Florida: Krieger Publishing Company. 359 pp. . Indian saw-scaled viper, little Indian viper,
a
Munich Antivenom Index
Accessed 13 September 2006. and by other

common names In biology, a common name of a taxon or organism (also known as a vernacular name, English name, colloquial name, country name, popular name, or farmer's name) is a name that is based on the normal language of everyday life; and is often contra ...

, is a

viper The Viperidae (vipers) are a family of snakes found in most parts of the world, except for Antarctica, Australia, Hawaii, Madagascar, and various other isolated islands. They are venomous and have long (relative to non-vipers), hinged fangs tha ...

species In biology, a species is the basic unit of classification and a taxonomic rank of an organism, as well as a unit of biodiversity. A species is often defined as the largest group of organisms in which any two individuals of the appropriate s ...

found in parts of the

Middle East The Middle East ( ar, الشرق الأوسط, ISO 233: ) is a geopolitical region commonly encompassing Arabian Peninsula, Arabia (including the Arabian Peninsula and Bahrain), Anatolia, Asia Minor (Asian part of Turkey except Hatay Pro ...

and

Central Asia Central Asia, also known as Middle Asia, is a subregion, region of Asia that stretches from the Caspian Sea in the west to western China and Mongolia in the east, and from Afghanistan and Iran in the south to Russia in the north. It includes t ...

, and especially the

Indian subcontinent The Indian subcontinent is a list of the physiographic regions of the world, physiographical region in United Nations geoscheme for Asia#Southern Asia, Southern Asia. It is situated on the Indian Plate, projecting southwards into the Indian O ...

. It is the smallest member of the " big four" Indian snakes that are responsible for causing the most

snakebite A snakebite is an injury caused by the bite of a snake, especially a venomous snake. A common sign of a bite from a venomous snake is the presence of two puncture wounds from the animal's fangs. Sometimes venom injection from the bite may occu ...

cases and deaths, due to various factors including their frequent occurrence in highly populated regions, and their inconspicuous nature.Whitaker Z (1990). ''Snakeman''. London: Penguin Books Ltd. 192 pp. . Like all vipers, the species is

venomous Venom or zootoxin is a type of toxin produced by an animal that is actively delivered through a wound by means of a bite, sting, or similar action. The toxin is delivered through a specially evolved ''venom apparatus'', such as fangs or a sti ...

. Two

subspecies In biological classification, subspecies is a rank below species, used for populations that live in different areas and vary in size, shape, or other physical characteristics (morphology), but that can successfully interbreed. Not all species ...

are currently recognized, including the

nominate subspecies In biological classification, subspecies is a rank below species, used for populations that live in different areas and vary in size, shape, or other physical characteristics (morphology), but that can successfully interbreed. Not all species ...

described here.

Description

The size of ''E. carinatus'' ranges between in total length (body + tail), but usually no more than . Head distinct from neck, snout very short and rounded. The nostril between three shields, and head covered with small

keeled scales Keeled scales refer to reptile scales that, rather than being smooth, have a ridge down the center that may or may not extend to the tip of the scale, Campbell, J. A., Lamar, W. W. (2004). ''The Venomous Reptiles of the Western Hemisphere''. Ithac ...

, among which an enlarged supraocular is sometimes present. There are 9-14 interocular scales across the top of the head and 14-21

circumorbital scales In scaled reptiles, the ocular scales are those forming the margin of the eye.Wright AH, Wright AA. 1957. ''Handbook of Snakes''. Comstock Publishing Associates (7th printing, 1985). 1105 pp. . The name originates from the term ''oculus'' which ...

. 1-3 rows of scales separate the eye from the supralabials. There are 10-12 supralabials, the fourth usually largest, and 10-13 sublabials. Boulenger GA (1890). ''The Fauna of British India, Including Ceylon and Burma. Reptilia and Batrachia.'' London: Secretary of State for India in Council. (Taylor and Francis, printers). xviii + 541 pp. (''"Echis carinata"'', pp. 422-423, Figure 124.)

Scalation

Midbody there are 25-39 rows of

dorsal scales In snakes, the dorsal scales are the longitudinal series of plates that encircle the body, but do not include the ventral scales. Campbell JA, Lamar WW (2004). ''The Venomous Reptiles of the Western Hemisphere''. Ithaca and London: Comstock Publis ...

that are keeled scales with apical pits; on the flanks, these have serrated keels. There are 143-189

ventral scales In snakes, the ventral scales or gastrosteges are the enlarged and transversely elongated scales that extend down the underside of the body from the neck to the anal scale. When counting them, the first is the anteriormost ventral scale that conta ...

that are rounded and cover the full width of the belly. The

subcaudals In snakes, the subcaudal scales are the enlarged plates on the underside of the tail.Wright AH, Wright AA. 1957. Handbook of Snakes. Comstock Publishing Associates (7th printing, 1985). 1105 pp. . These scales may be either single or divided (pair ...

are undivided and number 21-52, and the

anal scale Anal may refer to: Related to the anus *Related to the anus of animals: ** Anal fin, in fish anatomy ** Anal vein, in insect anatomy ** Anal scale, in reptile anatomy *Related to the human anus: ** Anal sex, a type of sexual activity involv ...

is single. The color-pattern consists of a pale buff, grayish, reddish, olive or pale brown ground color, overlaid middorsally with a series of variably colored, but mostly whitish spots, edged with dark brown, and separated by lighter interblotch patches. A series of white bows run dorsolaterally. The top of the head has a whitish cruciform or trident pattern and there is a faint stripe running from the eye to the angle of the jaw. The belly is whitish to pinkish, uniform in color or with brown dots that are either faint or distinct.

Common names

English English usually refers to: * English language * English people English may also refer to: Peoples, culture, and language * ''English'', an adjective for something of, from, or related to England ** English national ide ...

- saw-scaled viper, Indian saw-scaled viper, little Indian viper. * Sinhala - ''vali polonga (වැලි පොලඟා)''.Checklists of the Snakes of Sri Lanka
at th
Sri Lanka Wildlife Conservation Society
Accessed 15 August 2007. *

Odia Odia, also spelled Oriya or Odiya, may refer to: * Odia people in Odisha, India * Odia language, an Indian language, belonging to the Indo-Aryan branch of the Indo-European language family * Odia alphabet, a writing system used for the Odia languag ...

- ''Dhuli Naga''. *

Pushtu Pashto (,; , ) is an Eastern Iranian languages, Eastern Iranian language in the Indo-European languages, Indo-European language family. It is known in historical Persian literature as Afghani (). Spoken as a native language mostly by ethni ...

- ''phissi''.Daniels JC (2002). ''The Book of Indian Reptiles and Amphibians''. Mumbai: Bombay Natural History Society & Oxford University Press. 252 pp. 51-153 . *

Tamil Tamil may refer to: * Tamils, an ethnic group native to India and some other parts of Asia **Sri Lankan Tamils, Tamil people native to Sri Lanka also called ilankai tamils **Tamil Malaysians, Tamil people native to Malaysia * Tamil language, nativ ...

- ''surattai pambu''. ''viriyan pamboo'', ''surutai vireyan'' ( சுருட்டை விரியன் ) *

Telugu Telugu may refer to: * Telugu language, a major Dravidian language of India *Telugu people, an ethno-linguistic group of India * Telugu script, used to write the Telugu language ** Telugu (Unicode block), a block of Telugu characters in Unicode S ...

- ''Chinna pinjara'', ''thoti pinjara'' * Sindhi - ''kuppur'', ''janndi''. *

Marathi Marathi may refer to: *Marathi people, an Indo-Aryan ethnolinguistic group of Maharashtra, India *Marathi language, the Indo-Aryan language spoken by the Marathi people *Palaiosouda, also known as Marathi, a small island in Greece See also * * ...

- ''phoorsa'' ( ��ुरसं''). *

Kannada Kannada (; ಕನ್ನಡ, ), originally romanised Canarese, is a Dravidian language spoken predominantly by the people of Karnataka in southwestern India, with minorities in all neighbouring states. It has around 47 million native s ...

- ''kallu haavu''. *

Malayalam Malayalam (; , ) is a Dravidian language spoken in the Indian state of Kerala and the union territories of Lakshadweep and Puducherry (Mahé district) by the Malayali people. It is one of 22 scheduled languages of India. Malayalam was des ...

- ''anali'' അണലി *

Gujarati Gujarati may refer to: * something of, from, or related to Gujarat, a state of India * Gujarati people, the major ethnic group of Gujarat * Gujarati language, the Indo-Aryan language spoken by them * Gujarati languages, the Western Indo-Aryan sub ...

- ''tarachha'', ''zeri padkoo'' (ઝેરી પૈડકુ) ''udaneyn''. *

Hindi Hindi (Devanāgarī: or , ), or more precisely Modern Standard Hindi (Devanagari: ), is an Indo-Aryan language spoken chiefly in the Hindi Belt region encompassing parts of northern, central, eastern, and western India. Hindi has been de ...

- ''aphai'' (अफई) *

Russian Russian(s) refers to anything related to Russia, including: *Russians (, ''russkiye''), an ethnic group of the East Slavic peoples, primarily living in Russia and neighboring countries *Rossiyane (), Russian language term for all citizens and peo ...

- ''эфа песчаная''эфа песчаная
a
Floranimal.ru
Accessed 21 September 2008. *

Iraqi Arabic Mesopotamian Arabic, ( ar, لهجة بلاد ما بين النهرين) also known as Iraqi Arabic ( ar, اللهجة العراقية), or Gilit Mesopotamian Arabic (as opposed to North Mesopotamian Arabic, Qeltu Mesopotamian Arabic) is a contin ...

- Said Dekhil snake حية سيد دخيل *

Persian Persian may refer to: * People and things from Iran, historically called ''Persia'' in the English language ** Persians, the majority ethnic group in Iran, not to be conflated with the Iranic peoples ** Persian language, an Iranian language of the ...

: Jafaree snake مار جعفری *

Bengali Bengali or Bengalee, or Bengalese may refer to: *something of, from, or related to Bengal, a large region in South Asia * Bengalis, an ethnic and linguistic group of the region * Bengali language, the language they speak ** Bengali alphabet, the w ...

: ফুরসা বোড়া সাপ (Fursa boda sap), কাঁটা-আঁইশা বোড়া, খুঁদে চন্দ্রবোড়া, বোড়া সাপ, বঙ্করাজ। *

Tulu Tulu may refer to: People *Derartu Tulu (born 1972), Ethiopian long-distance runner *Walid Yacoubou (born 1997), Togolese footballer nicknamed "Tulu" India *Tulu calendar, traditional solar calendar generally used in the regions of southwest Kar ...

: ನೆತ್ತೆರ್ ಮೂಗೇಲ್ (netter mugel)

Geographic range

''Echis carinatus'' is

endemic Endemism is the state of a species being found in a single defined geographic location, such as an island, state, nation, country or other defined zone; organisms that are indigenous to a place are not endemic to it if they are also found elsew ...

Asia Asia (, ) is one of the world's most notable geographical regions, which is either considered a continent in its own right or a subcontinent of Eurasia, which shares the continental landmass of Afro-Eurasia with Africa. Asia covers an area ...

. On the

it is found in

India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...

Sri Lanka Sri Lanka (, ; si, ශ්‍රී ලංකා, Śrī Laṅkā, translit-std=ISO (); ta, இலங்கை, Ilaṅkai, translit-std=ISO ()), formerly known as Ceylon and officially the Democratic Socialist Republic of Sri Lanka, is an ...

Bangladesh Bangladesh (}, ), officially the People's Republic of Bangladesh, is a country in South Asia. It is the eighth-most populous country in the world, with a population exceeding 165 million people in an area of . Bangladesh is among the mos ...

, and

Pakistan Pakistan ( ur, ), officially the Islamic Republic of Pakistan ( ur, , label=none), is a country in South Asia. It is the world's List of countries and dependencies by population, fifth-most populous country, with a population of almost 24 ...

(including Urak near

Quetta Quetta (; ur, ; ; ps, کوټه‎) is the tenth List of cities in Pakistan by population, most populous city in Pakistan with a population of over 1.1 million. It is situated in Geography of Pakistan, south-west of the country close to the ...

and

Astola Island Astola Island ( ur, ) also known as ''Jezira Haft Talar'' (Urdu, ) ''Satadip'' or 'Island of the Seven Hills', is a small uninhabited Pakistani island in the Arabian Sea approximately south of the nearest part of the coast and southeast of the ...

off the coast of

Makran Makran ( fa, مكران), mentioned in some sources as Mecran and Mokrān, is the coastal region of Baluchistan. It is a semi-desert coastal strip in Balochistan, in Pakistan and Iran, along the coast of the Gulf of Oman. It extends westwards, ...

). In the

it is found in

Oman Oman ( ; ar, عُمَان ' ), officially the Sultanate of Oman ( ar, سلْطنةُ عُمان ), is an Arabian country located in southwestern Asia. It is situated on the southeastern coast of the Arabian Peninsula, and spans the mouth of t ...

, Masirah (Island), eastern

United Arab Emirates The United Arab Emirates (UAE; ar, اَلْإِمَارَات الْعَرَبِيَة الْمُتَحِدَة ), or simply the Emirates ( ar, الِْإمَارَات ), is a country in Western Asia (The Middle East). It is located at th ...

Iraq Iraq,; ku, عێراق, translit=Êraq officially the Republic of Iraq, '; ku, کۆماری عێراق, translit=Komarî Êraq is a country in Western Asia. It is bordered by Turkey to Iraq–Turkey border, the north, Iran to Iran–Iraq ...

, and southwestern

Iran Iran, officially the Islamic Republic of Iran, and also called Persia, is a country located in Western Asia. It is bordered by Iraq and Turkey to the west, by Azerbaijan and Armenia to the northwest, by the Caspian Sea and Turkmeni ...

. In

it is found in

Afghanistan Afghanistan, officially the Islamic Emirate of Afghanistan,; prs, امارت اسلامی افغانستان is a landlocked country located at the crossroads of Central Asia and South Asia. Referred to as the Heart of Asia, it is bordere ...

Uzbekistan Uzbekistan (, ; uz, Ozbekiston, italic=yes / , ; russian: Узбекистан), officially the Republic of Uzbekistan ( uz, Ozbekiston Respublikasi, italic=yes / ; russian: Республика Узбекистан), is a doubly landlocked cou ...

Turkmenistan Turkmenistan ( or ; tk, Türkmenistan / Түркменистан, ) is a country located in Central Asia, bordered by Kazakhstan to the northwest, Uzbekistan to the north, east and northeast, Afghanistan to the southeast, Iran to the sout ...

, and

Tajikistan Tajikistan (, ; tg, Тоҷикистон, Tojikiston; russian: Таджикистан, Tadzhikistan), officially the Republic of Tajikistan ( tg, Ҷумҳурии Тоҷикистон, Jumhurii Tojikiston), is a landlocked country in Centr ...

. The type locality was not included in the original description by Schneider (1801). However a locality had been given as "Arni" (India) by Russell (1796:3). There are also reports that this species occurs in

.Snakes and Spiders
a
Black Five
Accessed 6 January 2007.Joint Chiefs of Staff Campaign Analysis Report
Snakes & Scorpions in Iraq & Antivenin Sources.pdf Venomous Snakes and Scorpions in Iraq, and Their Antivenin Sources
a
311th Human Systems Wing, Brooks City-Base
. Accessed 6 January 2007. It is found in Thiqar and Kirkuk governorates

Habitat

''Echis carinatus'' is found on a range of different substrates, including sand, rock, soft soil and in scrublands. Often found hiding under loose rocks. Specimens have also been found in

Balochistan Balochistan ( ; bal, بلۏچستان; also romanised as Baluchistan and Baluchestan) is a historical region in Western and South Asia, located in the Iranian plateau's far southeast and bordering the Indian Plate and the Arabian Sea coastline. ...

at altitudes of up to 1982 m.

Behaviour

''Echis carinatus'' is mostly

crepuscular In zoology, a crepuscular animal is one that is active primarily during the twilight period, being matutinal, vespertine, or both. This is distinguished from diurnal and nocturnal behavior, where an animal is active during the hours of daylig ...

and nocturnal, although there have been reports of activity during daylight hours. During the daytime they hide in various locations, such as deep mammal burrows, rock fissures and fallen rotted logs. In sandy environments, they may bury themselves leaving only the head exposed. Often, they are most active after rains or on humid nights.Mehrtens JM (1987). ''Living Snakes of the World in Color''. New York: Sterling Publishers. 480 pp. . This species is often found climbing in bushes and shrubs, sometimes as much as 2 m above the ground. When it rains, up to 80% of the adult population will climb into bushes and trees. Once, it was observed that approximately 20 individuals had massed on top of a single cactus or small shrub. ''Echis carinatus'' is one of the species responsible for causing the most

cases due to their inconspicuous and extremely aggressive nature. Its characteristic pose, a double coil with a figure of eight, with the head poised in the center, permits it to lash out like a released spring. They move about mainly by sidewinding: a method at which they are considerably proficient and alarmingly quick. They are also capable of other forms of locomotion, but sidewinding seems to be best suited to moving about in their usual sandy habitats. It may also keep them from overheating too quickly, as there are only two points of contact with the hot surface in this form of locomotion. In the northern parts of its range, these snakes hibernate in winter.

Feeding

''Echis carinatus'' feeds on rodents,

lizard Lizards are a widespread group of squamate reptiles, with over 7,000 species, ranging across all continents except Antarctica, as well as most oceanic island chains. The group is paraphyletic since it excludes the snakes and Amphisbaenia alt ...

frog A frog is any member of a diverse and largely Carnivore, carnivorous group of short-bodied, tailless amphibians composing the order (biology), order Anura (ανοὐρά, literally ''without tail'' in Ancient Greek). The oldest fossil "proto-f ...

s, and a variety of

arthropod Arthropods (, (gen. ποδός)) are invertebrate animals with an exoskeleton, a Segmentation (biology), segmented body, and paired jointed appendages. Arthropods form the phylum Arthropoda. They are distinguished by their jointed limbs and Arth ...

s, such as

scorpion Scorpions are predatory arachnids of the order Scorpiones. They have eight legs, and are easily recognized by a pair of grasping pincers and a narrow, segmented tail, often carried in a characteristic forward curve over the back and always end ...

centipede Centipedes (from New Latin , "hundred", and Latin , " foot") are predatory arthropods belonging to the class Chilopoda (Ancient Greek , ''kheilos'', lip, and New Latin suffix , "foot", describing the forcipules) of the subphylum Myriapoda, an ...

s and large

insect Insects (from Latin ') are pancrustacean hexapod invertebrates of the class Insecta. They are the largest group within the arthropod phylum. Insects have a chitinous exoskeleton, a three-part body ( head, thorax and abdomen), three pairs ...

s. Diet may be varied according to availability of prey. High populations in some areas may be due to this generalist diet.

Reproduction

The population of ''E. carinatus'' in

ovoviviparous Ovoviviparity, ovovivipary, ovivipary, or aplacental viviparity is a term used as a "bridging" form of reproduction between egg-laying oviparous and live-bearing viviparous reproduction. Ovoviviparous animals possess embryos that develop insi ...

. In northern

, mating takes place in the winter with live young being born from April through August. Occasionally, births have also been recorded in other months. A litter usually consists of 3 to 15 young that are 115–152 mm in length. Mallow ''et al.'' (2003) mention a maximum litter size of 23. Juvenile Saw Scaled Viper

Venom

''Echis carinatus'' produces on average about 18 mg of dry venom by weight, with a recorded maximum of 72 mg. It may inject as much as 12 mg, whereas the lethal dose for an adult is estimated to be only 5 mg. Envenomation results in local symptoms as well as severe systemic symptoms that may prove fatal. Local symptoms include swelling and pain, which appear within minutes of a bite. In very bad cases the swelling may extend up the entire affected limb within 12–24 hours and blisters form on the skin.Ali G, Kak M, Kumar M, Bali SK, Tak SI, Hassan G, Wadhwa MB (2004). "Acute renal failure following ''Echis carinatus'' (saw–scaled viper) envenomation". '' Indian J. Nephrol.'' 14: 177-181
PDF
a
Indian Medlars Centre
. Accessed 12 September 2006. The venom yield from individual specimens varies considerably, as does the quantity injected per bite. The mortality rate from their bites is about 20%, and due to the availability of the anti-venom, deaths are currently quite rare. Of the more dangerous systemic symptoms,

hemorrhage Bleeding, hemorrhage, haemorrhage or blood loss, is blood escaping from the circulatory system from damaged blood vessels. Bleeding can occur internally, or externally either through a natural opening such as the mouth, nose, ear, urethra, vag ...

and coagulation defects are the most striking.

Hematemesis Hematemesis is the vomiting of blood. It is always an important sign. It can be confused with hemoptysis (coughing up blood) or epistaxis (nosebleed), which are more common. The source is generally the upper gastrointestinal tract, typically abo ...

melena Melena or melaena refers to the dark black, tarry feces that are associated with upper gastrointestinal bleeding. The black color and characteristic strong odor are caused by hemoglobin in the blood being altered by digestive enzymes and intest ...

hemoptysis Hemoptysis is the coughing up of blood or blood-stained mucus from the bronchi, larynx, trachea, or lungs. In other words, it is the airway bleeding. This can occur with lung cancer, infections such as tuberculosis, bronchitis, or pneumonia, and ...

hematuria Hematuria or haematuria is defined as the presence of blood or red blood cells in the urine. “Gross hematuria” occurs when urine appears red, brown, or tea-colored due to the presence of blood. Hematuria may also be subtle and only detectable w ...

and

epistaxis A nosebleed, also known as epistaxis, is bleeding from the nose. Blood can flow down into the stomach, and cause nausea and vomiting. In more severe cases, blood may come out of both nostrils. Rarely, bleeding may be so significant that low bloo ...

also occur and may lead to

hypovolemic shock Hypovolemic shock is a form of shock caused by severe hypovolemia (insufficient blood volume or extracellular fluid in the body). It could be the result of severe dehydration through a variety of mechanisms or blood loss. Hypovolemic shock is a ...

. Almost all patients develop

oliguria Oliguria or hypouresis is the low output of urine specifically more than 80 ml/day but less than 400ml/day.Boon et al, Davidson's Principles & Practice of Medicine (20th Ed), p475 The decreased output of urine may be a sign of dehydration, kidney ...

anuria Anuria is nonpassage of urine, in practice is defined as passage of less than 100Harrison's Principles of Internal Medicine, 19E PAGE 292 milliliters of urine in a day. Anuria is often caused by failure in the function of kidneys. It may also occu ...

within a few hours to as late as 6 days post bite. In some cases,

kidney dialysis Kidney dialysis (from Greek , , 'dissolution'; from , , 'through', and , , 'loosening or splitting') is the process of removing excess water, solutes, and toxins from the blood in people whose kidneys can no longer perform these functions natura ...

is necessary due to

acute kidney injury Acute kidney injury (AKI), previously called acute renal failure (ARF), is a sudden decrease in kidney function that develops within 7 days, as shown by an increase in serum creatinine or a decrease in urine output, or both. Causes of AKI are cla ...

(AKI), but this is not often caused by

hypotension Hypotension is low blood pressure. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. Blood pressure is indicated by two numbers, the systolic blood pressure (the top number) and the dias ...

. It is more often the result of intravascular

hemolysis Hemolysis or haemolysis (), also known by several other names, is the rupturing (lysis) of red blood cells (erythrocytes) and the release of their contents (cytoplasm) into surrounding fluid (e.g. blood plasma). Hemolysis may occur in vivo o ...

, which occurs in about half of all cases. In other cases, ARF is often caused by

disseminated intravascular coagulation Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body, blocking small blood vessels. Symptoms may include chest pain, shortness of breath, leg pain, problems speaking, or problems moving parts o ...

. In any case, antivenin therapy and intravenous hydration within hours of the bite are vital for survival. At least eight different polyvalent and monovalent antivenins are available against bites from this species. The venom from this species is used in the manufacture of several drugs. One is called ''echistatin'', which is an

anticoagulant Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where the ...

. Even though many other snake venoms contain similar toxins, ''echistatin'' is not only especially potent, but also simplistic in structure, which makes it easier to replicate. Indeed, it is obtained not only through the purification of whole venom,Echistatin from ''Echis carinatus''
at

Sigma-Aldrich Sigma-Aldrich (formally MilliporeSigma) is an American chemical, life science, and biotechnology company that is owned by the German chemical conglomerate Merck Group. Sigma-Aldrich was created in 1975 by the merger of Sigma Chemical Company a ...

. Accessed 29 September 2006. but also as a product of

chemical synthesis As a topic of chemistry, chemical synthesis (or combination) is the artificial execution of chemical reactions to obtain one or several products. This occurs by physical and chemical manipulations usually involving one or more reactions. In moder ...

.Saw-scaled Vipers
a
Electronic Medical Curriculum
. Accessed 29 September 2006.Garsky VM, Lumma PK, Freidinger RM, Pitzenberger SM, Randall WC, Veber DF, Gould RJ, Friedman PA (1989). "Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from ''Echis carinatus'': synthesis and biological activity of selected analogs". ''Proc. Natl. Acad. Sci.'' 86 (11): 4022–4026
PDF
a
PubMed Central
Accessed 29 September 2006. Another drug made from ''E. carinatus'' venom is called '' ecarin'' and is the primary reagent in the ecarin clotting time (ECT) test, which is used to monitor anticoagulation during treatment with

hirudin Hirudin is a naturally occurring peptide in the salivary glands of blood-sucking leeches (such as ''Hirudo medicinalis'') that has a blood anticoagulant property. This is fundamental for the leeches’ habit of feeding on blood, since it keeps a h ...

.Fabrizio MC (2001). "Use of Ecarin Clotting Time (ECT) with Lepirudin Therapy in Heparin-Induced Thrombocytopenia and Cardiopulmonary Bypass". '' J. American Soc. Extracorporeal Tech.'' 33: 117–125
PDF
a
Journal of The American Society of ExtraCorporeal Technology
Accessed 5 June 2007.Textarin/Ecarin Time
at
Specialty Laboratories
Accessed 5 June 2007. Yet another drug produced from ''E. carinatus'' venom is Aggrastat (Tirofiban). As of November 2016, an antivenom is currently being developed by the

Costa Rica Costa Rica (, ; ; literally "Rich Coast"), officially the Republic of Costa Rica ( es, República de Costa Rica), is a country in the Central American region of North America, bordered by Nicaragua to the north, the Caribbean Sea to the no ...

Clodomiro Picado Institute The Instituto Clodomiro Picado is a research center in Vázquez de Coronado (canton), Vázquez de Coronado, San José Province, Costa Rica. Established in 1970, the institute is a research unit of the Universidad de Costa Rica, responsible for the ...

, and clinical trial phase in Sri Lanka.Rodrigo M (2016). ''Trials to start for home-grown anti-venom''. Available at: http://www.sundaytimes.lk/161009/news/trials-to-start-for-home-grown-anti-venom-211742.html

Description

Scalation

Common names

Geographic range

Habitat

Behaviour

Feeding

Reproduction

Venom

Subspecies

References

Further reading

External links