Estrogen-related receptor beta (ERR-β), also known as ESRRB or NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a
nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These receptors work with other proteins to regulate the expression of speci ...
that in humans is encoded by the ''ESRRB'' (Estrogen Related Receptor Beta)
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
ESRRB has been shown to be vital for the transition between a
naïve pluripotent and primed pluripotent state in mammalian cells, and
NANOG controls the expression of ESRRB in this scenario.
References
Further reading
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{{Estrogen-related receptor modulators
Intracellular receptors
Transcription factors