ERG3 or sterol C-5 desaturase is a
fungal enzyme originally from ''
Saccharomyces cerevisiae'', the
human ortholog of ERG3 is
SC5D. ERG3 localizes to both the endoplasmic reticulum and
vesicles
Vesicle may refer to:
; In cellular biology or chemistry
* Vesicle (biology and chemistry), a supramolecular assembly of lipid molecules, like a cell membrane
* Synaptic vesicle
; In human embryology
* Vesicle (embryology), bulge-like features o ...
, catalyzes the C5(6)-dehydrogenation of
episterol to
5-dehydroepisterol, 5-Dehydroepisterol will be further converted into
ergosterol
Ergosterol (ergosta-5,7,22-trien-3β-ol) is a sterol found in cell membranes of fungi and protozoa, serving many of the same functions that cholesterol serves in animal cells. Because many fungi and protozoa cannot survive without ergosterol, the ...
.
See also
*
C-5 sterol desaturase
C-5 sterol desaturase (also known as sterol C-5 desaturase and C5SD) is an enzyme that is highly conserved among eukaryotes and catalyzes the dehydrogenation of a C-5(6) bond in a sterol intermediate compound as a step in the biosynthesis of major ...
*
Δ7-sterol 5(6)-desaturase
References
EC 1.14.19
Saccharomyces cerevisiae genes
{{Enzyme-stub