EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a
protein encoded by the ''ADGRE1''
gene.
EMR1 is a member of the
adhesion GPCR family.
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing
(GAIN) domain.
EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells. The murine homolog of EMR1, F4/80, is a well-known and widely used marker of murine macrophage populations. The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (
EGF-like) domains in human and 4-7 EGF-like domains in the mouse.
Function
Utilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8
+ regulatory T cells needed for peripheral tolerance.
Clinical significance
Legrand et al. demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.
See also
*
EGF module-containing mucin-like hormone receptor
The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like dom ...
References
External links
GPCR consortium
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G protein-coupled receptors