EMPA is a selective
antagonist of the
OX2 receptor, with 900-fold
selectivity in binding for OX
2 over
OX1.
See also
*
TCS-OX2-29
TCS-OX2-29 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX2, with an IC50 of 40nM and selectivity of around 250x for OX2 over OX1 receptors. Orexin antagonists ar ...
References
Orexin antagonists
Pyridines
Sulfonamides
{{nervous-system-drug-stub