Protein argonaute-2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''EIF2C2''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
This gene encodes a member of the
Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a
PAZ domain and a
PIWI domain
Piwi (or PIWI) genes were identified as regulatory proteins responsible for stem cell and germ cell differentiation. Piwi is an abbreviation of P-element Induced WImpy testis in ''Drosophila''. Piwi proteins are highly conserved RNA-bindi ...
. It may interact with
Dicer1
Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short d ...
and play a role in short-interfering-RNA-mediated gene silencing.
Interactions
EIF2C2 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
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DDX20
Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded by the ''DDX20'' gene.
Function
DEAD box proteins, characterized by the conserved motif ...
,
*
DICER1
Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short d ...
,
TNRC6B
Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the ''TNRC6B'' gene.
Interactions
TNRC6B has been shown to interact with EIF2C2. It is also known to associate with argonaute proteins and has been shown ...
.
References
Further reading
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RNA interference
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