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EIDD-1723, also known as EPRX-01723 or as progesterone 20''E''- 'O''-[(phosphonooxy)methylxime">phosphonooxy)methyl.html" ;"title="'O''-[(phosphonooxy)methyl">'O''-[(phosphonooxy)methylximesodium salt, is a synthetic compound">synthetic Synthetic things are composed of multiple parts, often with the implication that they are artificial. In particular, 'synthetic' may refer to: Science * Synthetic chemical or compound, produced by the process of chemical synthesis * Synthetic o ...
, water-soluble structural analog, analogue of progesterone (medication), progesterone and a neurosteroid which was developed for the potential treatment of traumatic brain injury.Guthrie, D. B., Lockwood, M. A., Natchus, M. G., Liotta, D. C., Stein, D. G., & Sayeed, I. (2017). U.S. Patent No. 9,802,978. Washington, DC: U.S. Patent and Trademark Office. https://patents.google.com/patent/US9802978B2/en It is a rapidly converted
prodrug A prodrug is a medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug ...
of EIDD-036 (EPRX-036; progesterone 20-oxime), which is considered to be the active form of the agent. Previous C3 and C20 oxime derivatives of progesterone, such as P1-185 (progesterone 3-''O''-(-valine)-''E''-oxime), were also developed and studied prior to EIDD-1723.


See also

* List of neurosteroids § Inhibitory > Synthetic > Pregnanes * List of progestogen esters § Oximes of progesterone derivatives


References

Experimental drugs Enones Neuroprotective agents Neurosteroids Organic sodium salts Phosphate esters Pregnanes Prodrugs Steroid oximes {{Nervous-system-drug-stub