Caspase-2 (, ''ICH-1'', ''NEDD-2'', ''caspase-2L'', ''caspase-2S'', ''neural precursor cell expressed developmentally down-regulated protein 2'', ''CASP-2'', ''NEDD2 protein'') is an enzyme. This enzyme catalyses the following chemical reaction : Strict requirement for an Asp residue at P1, with Asp³¹⁶ being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp- Caspase-2 is an initiator

caspase Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death. They are named caspases due to their specific cystei ...

, as are caspase-8 (

EC 3.4.22.61 Caspase-8 is a caspase protein, encoded by the ''CASP8'' gene. It most likely acts upon caspase-3. ''CASP8'' orthologs have been identified in numerous mammals for which complete genome data are available. These unique orthologs are also prese ...

), caspase-9 (

EC 3.4.22.62 Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, critical to the apoptotic pathway found in many tissues. Caspase-9 homologs have been identified in all mammals for which they are known to exist, such ...

) and caspase-10 (

EC 3.4.22.63 Caspase-10 (, ''FLICE2, Mch4'', ''CASP-10'', ''ICE-like apoptotic protease 4'', ''apoptotic protease Mch-4'', ''FAS-associated death domain protein interleukin-1beta-converting enzyme 2'') is an enzyme. This enzyme catalyses the following chemical ...

References

External links

* {{Portal bar, Biology, border=no EC 3.4.22