In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, an UDP-N-acetylmuramate dehydrogenase () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:UDP-N-acetyl-alpha-D-muramate + NADP
+ UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H
+
Thus, the two
substrates of this enzyme are
UDP-N-acetyl-alpha-D-muramate and
NADP+, whereas its 3
products are
UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine,
NADPH
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NAD ...
, and
H+.
This enzyme belongs to the family of
oxidoreductases, specifically those acting on the CH-CH group of donor with NAD
+ or NADP
+ as acceptor. The
systematic name of this enzyme class is UDP-N-acetyl-alpha-D-muramate:NADP
+ oxidoreductase. Other names in common use include MurB reductase, UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylglucosamine-enoylpyruvate reductase, UDP-GlcNAc-enoylpyruvate reductase, uridine diphosphoacetylpyruvoylglucosamine reductase, uridine diphospho-N-acetylglucosamine-enolpyruvate reductase, uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase. This enzyme participates in
aminosugars metabolism
In organic chemistry, an amino sugar (or more technically a 2-amino-2-deoxysugar) is a sugar molecule in which a hydroxyl group has been replaced with an amine group. More than 60 amino sugars are known, with one of the most abundant being ''N''- ...
. It employs one
cofactor,
FAD
A fad or trend is any form of collective behavior that develops within a culture, a generation or social group in which a group of people enthusiastically follow an impulse for a short period.
Fads are objects or behaviors that achieve short- ...
.
Structural studies
As of late 2007, 8
structures have been solved for this class of enzymes, with
PDB accession codes , , , , , , , and .
References
*
*
*
EC 1.3.1
NADPH-dependent enzymes
Flavoproteins
Enzymes of known structure
{{1.3-enzyme-stub