Denise Darvall
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__NOTOC__ Denise Darvall (27 February 19423 December 1967) was the
donor A donor in general is a person, organization or government which donates something voluntarily. The term is usually used to represent a form of pure altruism, but is sometimes used when the payment for a service is recognized by all parties as rep ...
in the world's first successful human
heart transplant A heart transplant, or a cardiac transplant, is a surgical transplant procedure performed on patients with end-stage heart failure or severe coronary artery disease when other medical or surgical treatments have failed. , the most common proce ...
, performed at
Groote Schuur Hospital Groote Schuur Hospital is a large, government-funded, teaching hospital situated on the slopes of Devil's Peak in the city of Cape Town, South Africa. It was founded in 1938 and is famous for being the institution where the first human-to-huma ...
,
South Africa South Africa, officially the Republic of South Africa (RSA), is the southernmost country in Africa. It is bounded to the south by of coastline that stretch along the South Atlantic and Indian Oceans; to the north by the neighbouring countri ...
, by a team of surgeons led by
Christiaan Barnard Christiaan Neethling Barnard (8 November 1922 – 2 September 2001) was a South African cardiac surgeon who performed the world's first human-to-human heart transplant operation. On 3 December 1967, Barnard transplanted the heart of accident-v ...
.


Accident and death


Injuries

Denise Darvall was seriously injured in a car accident on Main Road in
Observatory An observatory is a location used for observing terrestrial, marine, or celestial events. Astronomy, climatology/meteorology, geophysical, oceanography and volcanology are examples of disciplines for which observatories have been constructed. His ...
,
Cape Town Cape Town ( af, Kaapstad; , xh, iKapa) is one of South Africa's three capital cities, serving as the seat of the Parliament of South Africa. It is the legislative capital of the country, the oldest city in the country, and the second largest ...
. She and her family were visiting friends for afternoon tea and went shopping for cake. She and her mother, Myrtle Ann Darvall, were run over by salesman and police reservist Frederick Prins, who failed to see them. This was due to a large truck that obscured his view of them, and their view of his car. Her mother died immediately. Denise Darvall sustained a
skull fracture A skull fracture is a break in one or more of the eight bones that form the cranial portion of the human skull, skull, usually occurring as a result of blunt force trauma. If the force of the impact is excessive, the bone may fracture at or near ...
and severe head injuries after the car flung her across the road; her head hit the wheel cap of her car. She required
life support Life support comprises the treatments and techniques performed in an emergency in order to support life after the failure of one or more vital organs. Healthcare providers and emergency medical technicians are generally certified to perform basic ...
to remain alive, and was essentially
brain dead Brain death is the permanent, irreversible, and complete loss of brain function which may include cessation of involuntary activity necessary to sustain life. It differs from persistent vegetative state, in which the person is alive and some aut ...
by the time she made it into the hospital. At 9 p.m. on the day of the accident, the resuscitation team stopped attempts to revive her.


Father gives permission

Edward Darvall arranged for his fourteen-year-old son, who had witnessed the accident, to be taken away from the hospital. The 66-year-old Edward was also given a sedative, and he waited while doctor's attempted to save his daughter.Two doctors, Coert Venter and Bertie Bosman, informed him that there was nothing further they could do for Denise.Bosman explained that there was a man in the hospital they might be able to help, and asked Edward if he would consider allowing them to transplant Denise's heart. Edward Darvall later said that, after thinking about his daughter for four minutes, he reached his decision and gave permission.


Declaration of death

Surgeons had a serious ethical problem because death then could only be declared by whole-body standards. The Harvard Criteria of
brain death Brain death is the permanent, irreversible, and complete loss of brain function which may include cessation of involuntary activity necessary to sustain life. It differs from persistent vegetative state, in which the person is alive and some aut ...
were not developed until 1968, nor were they adopted in South Africa or elsewhere for some years. The problem in this case was that, although Denise's brain was damaged, her heart was healthy. Various reports over the years attributed conflicting reasons for her heart stopping. For 40 years, Marius Barnard kept a secret: rather than wait for her heart to stop beating, his brother,
Christiaan Barnard Christiaan Neethling Barnard (8 November 1922 – 2 September 2001) was a South African cardiac surgeon who performed the world's first human-to-human heart transplant operation. On 3 December 1967, Barnard transplanted the heart of accident-v ...
, who led the transplant team, had injected
potassium Potassium is the chemical element with the symbol K (from Neo-Latin ''kalium'') and atomic number19. Potassium is a silvery-white metal that is soft enough to be cut with a knife with little force. Potassium metal reacts rapidly with atmosphe ...
into Denise's heart to paralyze it at Marius's urging. This rendered her technically dead by the whole-body standard.


Organ donation

After her father gave his consent, Darvall's
heart The heart is a muscular organ in most animals. This organ pumps blood through the blood vessels of the circulatory system. The pumped blood carries oxygen and nutrients to the body, while carrying metabolic waste such as carbon dioxide t ...
was donated to
Louis Washkansky Louis Joshua Washkansky (12 April 1912 – 21 December 1967) was a South African man who was the recipient of the world's first human-to-human heart transplant, and the first patient to regain consciousness following the operation. Washkansky l ...
. Her
kidney The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood ...
s were given to 10-year-old Jonathan van Wyk. Due to
apartheid Apartheid (, especially South African English: , ; , "aparthood") was a system of institutionalised racial segregation that existed in South Africa and South West Africa (now Namibia) from 1948 to the early 1990s. Apartheid was ...
, the kidney donation to Van Wyk was controversial because he was
khoi Khoekhoen (singular Khoekhoe) (or Khoikhoi in the former orthography; formerly also '' Hottentots''"Hottentot, n. and adj." ''OED Online'', Oxford University Press, March 2018, www.oed.com/view/Entry/88829. Accessed 13 May 2018. Citing G. S. ...
, while Denise was
white White is the lightest color and is achromatic (having no hue). It is the color of objects such as snow, chalk, and milk, and is the opposite of black. White objects fully reflect and scatter all the visible wavelengths of light. White on ...
. Washkansky lived 18 days before succumbing to pneumonia.


Burial and trial

Edward Darvall arranged for his wife and daughter to be cremated at the Maitland Crematorium,
Maitland, Cape Town Maitland is a suburb of Cape Town, South Africa. Maitland is situated along a number of important transport networks connecting the Cape Town city bowl to the rest of the city. The most important being the railway line that runs through the mi ...
. The joint ceremony took place on Wednesday, 6 December, and their ashes were later placed into a niche on site. Edward Darvall died in 1970 and was also cremated there. Darvall was present at the trial of the drunk driver who was convicted of murder. He made a statement through a lawyer, asking the magistrate to show the "greatest possible mercy" to the driver, "The tragic death of his daughter was not meaningless, but benefited humanity," he said.


References


Bibliography

*Christiaan Barnard and Curtiss Bill Pepper, "One Life," MacMillan, New York, 1969. *Christiaan Barnard, "The Second Life," Vlaeberg Publishers, South Africa, 1993.


External links


South African history: Denise Darvall
{{DEFAULTSORT:Darvall, Denise 1942 births 1967 deaths Organ transplant donors Road incident deaths in South Africa White South African people