Dynamin Superfamily Protein (DSP) is a
protein superfamily
A protein superfamily is the largest grouping (clade) of proteins for which common ancestry can be inferred (see homology (biology), homology). Usually this common ancestry is inferred from structural alignment and mechanistic similarity, even if n ...
includes classical
dynamins,
GBP
Sterling (abbreviation: stg; Other spelling styles, such as STG and Stg, are also seen. ISO code: GBP) is the currency of the United Kingdom and nine of its associated territories. The pound ( sign: £) is the main unit of sterling, and t ...
s,
Mx proteins,
OPA1
Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the ''OPA1'' gene. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis an ...
,
mitofusins in
Eukaryote
Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bacte ...
, and bacterial dynamin-like proteins (BDLPs) in
Prokaryote.
DSPs mediate eukaryotic
membrane fusion and
fission
Fission, a splitting of something into two or more parts, may refer to:
* Fission (biology), the division of a single entity into two or more parts and the regeneration of those parts into separate entities resembling the original
* Nuclear fissio ...
necessary for
endocytosis
Endocytosis is a cellular process in which substances are brought into the cell. The material to be internalized is surrounded by an area of cell membrane, which then buds off inside the cell to form a vesicle containing the ingested material. E ...
,
organelle biogenesis and maintenance,
Mitochondrial fusion and
fission
Fission, a splitting of something into two or more parts, may refer to:
* Fission (biology), the division of a single entity into two or more parts and the regeneration of those parts into separate entities resembling the original
* Nuclear fissio ...
, as well as for
prokaryotic cytokinesis.
Structure
All DSPs have two common
domains: a
GTPase domain and an elongated
α-helical bundle domain.
[
]
References
External links
{{Portal bar, Biology, border=no
Cellular processes
EC 3.6.5