Drug-naïve
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Drug naïvety is the physiological state of non-
habituation Habituation is a form of non-associative learning in which an innate (non-reinforced) response to a stimulus decreases after repeated or prolonged presentations of that stimulus. Responses that habituate include those that involve the intact org ...
or non- tolerance to either a specific drug or broader set of drugs related by pharmacological criteria. The term applies to the administration of
psychotropics A psychoactive drug, psychopharmaceutical, psychoactive agent or psychotropic drug is a chemical substance, that changes functions of the nervous system, and results in alterations in perception, mood, consciousness, cognition or behavior. T ...
in contexts ranging from the professional medical treatment of
patients A patient is any recipient of health care services that are performed by healthcare professionals. The patient is most often ill or injured and in need of treatment by a physician, nurse, optometrist, dentist, veterinarian, or other health c ...
to the non-medical
abuse Abuse is the improper usage or treatment of a thing, often to unfairly or improperly gain benefit. Abuse can come in many forms, such as: physical or verbal maltreatment, injury, assault, violation, rape, unjust practices, crimes, or other t ...
of any drug, as well as the veterinarian. In addition to not being habituated, a drug-naïve person may have never received a particular drug. The same dose could be lethal for a drug-naïve person while having little effect on a heavily habituated person. In a medical context drug-naïvete is important considering medication dosage (pain medication, anxiety medication, anaesthesia, etc.), as the level of habituation affects a patient's baseline resistance to the effects of such medications.


See also

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Scientific control A scientific control is an experiment or observation designed to minimize the effects of variables other than the independent variable (i.e. confounding variables). This increases the reliability of the results, often through a comparison betwe ...


Notes and references

Psychoactive drugs {{Psychoactive-stub