Reticular pigmented anomaly of the flexures (also known as dark dot disease and Dowling–Degos disease) is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.
[James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. .] It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.
Dark dot disease is associated with ''
KRT5''.
See also
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List of cutaneous conditions
Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against t ...
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List of cutaneous conditions caused by mutations in keratins
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Skin lesion
References
External links
Disturbances of human pigmentation
{{Cutaneous-condition-stub