Douglas L. Mann is an American physician. He is currently the Lewin Distinguished Professor in Cardiovascular Diseases and professor of medicine, cell biology and physiology at Washington University School of Medicine in St. Louis.

Education

Mann received his undergraduate training at Lafayette College, in Easton, Pennsylvania and his Medical degree from

Temple University School of Medicine The Lewis Katz School of Medicine at Temple University (LKSOM), located on the Health Science Campus of Temple University in Philadelphia, PA, is one of 7 schools of medicine in Pennsylvania conferring the M.D. (Doctor of Medicine) degree. It also ...

, Philadelphia, Pennsylvania. After finishing his residency in medicine at Temple University Hospital, he completed his cardiology fellowship at the

University of California The University of California (UC) is a public land-grant research university system in the U.S. state of California. The system is composed of the campuses at Berkeley, Davis, Irvine, Los Angeles, Merced, Riverside, San Diego, San Francisco, ...

, San Diego. He was a clinical and research fellow at the

Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is the original and largest teaching hospital of Harvard Medical School located in the West End neighborhood of Boston, Massachusetts. It is the third oldest general hospital in the United Stat ...

, Boston, Massachusetts and a research fellow in cardiology at Temple University Hospital. Prior to joining the faculty at Washington University School of Medicine in St. Louis, he was on staff at the

Medical University of South Carolina The Medical University of South Carolina (MUSC) is a public medical school in South Carolina. It opened in 1824 in Charleston as a small private college aimed at training physicians and has since established hospitals and medical facilities acr ...

and

Baylor College of Medicine Baylor College of Medicine (BCM) is a medical school and research center in Houston, Texas, within the Texas Medical Center, the world's largest medical center. BCM is composed of four academic components: the School of Medicine, the Graduate Sc ...

. He has been on the faculty at Washington University School of Medicine in St. Louis, where he was the chief of the cardiovascular division.

Research and career

Mann's research on the cellular and molecular basis for

heart failure Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome, a group of signs and symptoms caused by an impairment of the heart's blood pumping function. Symptoms typically include shortness of breath, excessive fatigue, a ...

have uncovered an important role for innate immunity in disease progression in the failing heart. He demonstrated that the heart expresses pro-inflammatory

cytokine Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are peptides and cannot cross the lipid bilayer of cells to enter the cytoplasm. Cytokines have been shown to be involved in autocrin ...

s following cardiac injury and that the expression of pro-inflammatory cytokines mimics the heart failure phenotype in experimental models. Clinically, Mann has translated his basic research observations into phase I and phase III trials that have targeted inflammatory pathways in heart failure.

Awards and honors

Mann is a member of the American Society for Clinical Investigation, the American Association of Physicians, the

Heart Failure Society of America The Heart Failure Society of America is an American organization of heart failure experts who have an interest in heart function and heart failure. Founded in 1995, it provides a forum for experts and patients with the aim of reducing the burde ...

, the

American Clinical and Climatological Association The American Clinical and Climatological Association (ACCA) is a society for the study of climatology, balneology, and the diseases of the respiratory and circulatory organs. It is composed of physicians residing in the United States and Canada. It ...

and is a fellow of the American College of Cardiology. His is the editor-in-chief of '' JACC: Basic to Translational Science'', and an editor for ''Braunwald’s Heart Disease.'' He has received numerous awards including the

Michael E. DeBakey Michael Ellis DeBakey (September 7, 1908 – July 11, 2008) was a Lebanese-American general and cardiovascular surgeon, scientist and medical educator who became Chairman of the Department of Surgery, President, and Chancellor of Baylor College ...

award for excellence in research, the Distinguished Mentor Award, American College of Cardiology, and the 2019 Lifetime achievement award from the Heart Failure Society of America and the 2020 lifetime achievement award from the European Heart Failure Association. He is the past president of the Heart Failure Society and the Medical Alumnus of the Year award from Temple University School of Medicine. He was recognized by Forbes magazine as one of the top 27 cardiologists in the United States.

References

{{DEFAULTSORT:Mann, Douglas L. 20th-century American physicians Year of birth missing (living people) Living people Lafayette College alumni Temple University School of Medicine alumni Medical University of South Carolina faculty Washington University School of Medicine faculty Baylor College of Medicine faculty 21st-century American physicians American cardiologists Academic journal editors Fellows of the American College of Cardiology