Double-stranded uracil-DNA glycosylase (, ''Mug'', ''double-strand uracil-DNA glycosylase'', ''Dug'', ''dsUDG'', ''double-stranded DNA specific UDG'', ''dsDNA specific UDG'', ''UdgB'', ''G:T/U mismatch-specific DNA glycosylase'', ''UDG'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
''uracil-double-stranded DNA deoxyribohydrolase (uracil-releasing)''.
This enzyme
catalyses a specific
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
: it
hydrolyses
Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution, elimination, and solvation reactions in which water is the nucleophile.
Biological hydrolysis ...
mismatched
double-stranded DNA and
polynucleotide
A polynucleotide molecule is a biopolymer composed of 13 or more nucleotide monomers covalently bonded in a chain. DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) are examples of polynucleotides with distinct biological function. The pre ...
s, releasing free
uracil
Uracil () (symbol U or Ura) is one of the four nucleobases in the nucleic acid RNA. The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by ...
.
This enzyme is not active on DNA containing a T/G mispair or single-stranded DNA.
References
External links
*
EC 3.2.2
{{3.2-enzyme-stub