Dosage Forms

Dosage forms (also called unit doses) are pharmaceutical drug products in the form in which they are marketed for use, with a specific mixture of active ingredients and inactive components ( excipients), in a particular configuration (such as a capsule shell, for example), and apportioned into a particular dose. For example, two products may both be amoxicillin, but one is in 500 mg capsules and another is in 250 mg chewable tablets. The term unit dose can also sometimes encompass non-reusable ''packaging'' as well (especially when each drug product is individually packaged), although the FDA distinguishes that by ''unit-dose "packaging" or "dispensing"''. Depending on the context, ''multi(ple) unit dose'' can refer to distinct drug products ''packaged'' together, or to a ''single'' drug product containing multiple drugs and/or doses. The term dosage form can also sometimes refer ''only'' to the pharmaceutical formulation of a drug product's constituent drug substance(s) and any blends involved, without considering matters beyond that (like how it is ultimately configured as a consumable product such as a capsule, patch, etc.). Because of the somewhat vague boundaries and unclear overlap of these terms and certain variants and qualifiers within the pharmaceutical industry, caution is often advisable when conversing with someone who may be unfamiliar with another person's use of the term.

Depending on the method/route of administration, dosage forms come in several types. These include many kinds of liquid, solid, and semisolid dosage forms. Common dosage forms include pill, tablet, or capsule, drink or syrup, among many others.

When one drug product (for example, one tablet, one capsule, one syrup) contains more than one drug (more than one active ingredient), that product is a combination drug (fixed-dose combination; FDC).

In naturopathy, dosages can take the form of decoctions and herbal teas, as well as the more conventional methods previously mentioned.

The route of administration (ROA) for drug delivery is dependent on the dosage form of the substance in question. Various dosage forms may exist for a single particular drug, since some medical conditions such as being unconscious can restrict ROA. For example, persistent nausea, especially with vomiting, may make it difficult to use an oral dosage form, and in such a case, it may be necessary to use an alternative route such as inhalational, buccal, sublingual, nasal, suppository or parenteral instead. Additionally, a specific dosage form may be a requirement for certain kinds of drugs, as there may be issues with various factors like chemical stability or pharmacokinetics. As an example, insulin cannot be given orally because upon being administered in this manner, it is extensively metabolized in the gastrointestinal tract (GIT) before reaching the blood stream, and is thereby incapable of sufficiently reaching its therapeutic target destinations. The oral and intravenous doses of a drug such as paracetamol will differ for the same reason.

Oral

* Pills, i.e. tablets or capsules
* Liquids such as syrups, solutions, elixers, emulsions, and tinctures
* Liquids such as decoctions and herbal teas
* Orally disintegrating tablets
* Lozenges or candy ( electuaries)
* Thin films (e.g., Listerine Pocketpaks, nitroglycerin) to be placed on top of or underneath the tongue as well as against the cheek
* Powders or effervescent powder or tablets, often instructed to be mixed into a food item
* Plants or seeds prepared in various ways such as a cannabis edible
* Pastes such as high fluoride toothpastes
* Gases such as oxygen (can also be delivered through the nose)

Ophthalmic

* Eye drops
* Lotions
* Ointments
* Emulsions

Inhalation

* Aerosolized medication
* Dry-powder Inhalers or metered dose inhalers
* Nebulizer-administered medication
* Smoking
* Vaporizer-administered medication

Unintended ingredients

Talc is an excipient often used in pharmaceutical tablets that may end up being crushed to a powder against medical advice or for recreational use. Also, illicit drugs that occur as white powder in their pure form are often cut with cheap talc. Natural talc is cheap but contains asbestos while asbestos-free talc is more expensive. Inhaled talc that has asbestos is generally accepted as being able to cause lung cancer if it is inhaled. The evidence about asbestos-free talc is less clear, according to the American Cancer Society.

Injection

Parenteral

* Intradermally-administered (ID)
* Subcutaneously-administered (SC)
* Intramuscularly-administered (IM)
* Intraosseous administration (IO)
* Intraperitoneally-administered (IP)
* intravenously-administered (IV)
* Intracavernously-administered (ICI)

These are usually solutions and suspensions.

Unintended ingredients

Safe

Eye drops (normal saline in disposable packages) are distributed to syringe users by needle exchange programs.

Unsafe

The injection of talc from crushed pills has been associated with pulmonary talcosis in intravenous drug users.

Topical

* Creams, liniments, balms (such as lip balm or antiperspirants and deodorants), lotions, or ointments, etc.
* Gels and hydrogels
* Ear drops
* Transdermal and dermal patches to be applied to the skin
* Powders

Unintended use

* It is not safe to calculate divided doses by cutting and weighing medical skin patches, because there's no guarantee that the substance is evenly distributed on the patch surface. For example, fentanyl transdermal patches are designed to slowly release the substance over 3 days. It is well known that cut fentanyl transdermal consumed orally have cause overdoses and deaths.
* Single blotting papers for illicit drugs injected from solvents in syringes may also cause uneven distribution across the surface.

Other

* Intravaginal administration
** Vaginal rings
** Capsules and tablets
** Suppositories
* Rectal administration (enteral)
** Suppositories
** Suspensions and solutions in the form of enemas
** Gels
* Urethral
* Nasal sprays

See also

* Classification of Pharmaco-Therapeutic Referrals
* Drug delivery
* Route of administration
* Pharmaceutical packaging

References

External links

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Dosage From Development

{{DEFAULTSORT:Dosage Form

Pharmacokinetics