Dorothea Zucker-Franklin
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Dorothea Zucker-Franklin (August 9, 1929 – November 24, 2015) was a physician and medical researcher in the fields of
hematology Hematology ( always spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. It involves treating diseases that affect the produc ...
,
immunology Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there ...
and
cell biology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and ...
. Born in Berlin, Germany, she fled to Amsterdam with her family in 1936 to escape the Nazi regime. In 1948, the family emigrated to New York, where Zucker-Franklin attended
Hunter College Hunter College is a public university in New York City. It is one of the constituent colleges of the City University of New York and offers studies in more than one hundred undergraduate and postgraduate fields across five schools. It also admi ...
for her undergraduate education and earned a medical degree from
New York Medical College New York Medical College (NYMC or New York Med) is a private medical school in Valhalla, New York. Founded in 1860, it is a member of the Touro College and University System. NYMC offers advanced degrees through its three schools: the School o ...
. Following her internship and residency, she trained in
electron microscopy An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination. As the wavelength of an electron can be up to 100,000 times shorter than that of visible light photons, electron microscopes have a hi ...
, and would become well-known for her use of this technique to study blood cells. She began teaching at the
New York University School of Medicine NYU Grossman School of Medicine is a medical school of New York University, a private research university in New York City. It was founded in 1841 and is one of two medical schools of the university, with the other being the Long Island School of ...
in 1963 and became a full professor in 1974. She was a member of the National Academy of Medicine and a fellow of the
American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...
, and served as president of the Society for Leukocyte Biology in 1985 and the
American Society of Hematology The American Society of Hematology (ASH) is a professional organization representing hematologists. It was founded in 1958. Its annual meeting is held in December of every year and has attracted more than 30,000 attendees. The society publishes th ...
in 1995.


Early life and education

Zucker-Franklin was born into a Jewish family on August 9, 1929, in Berlin, Germany. Her parents were Julius Zucker, a merchant, and Gertrude Zucker (née Feige), a Prussian-born musician. In the wake of the Nazi Party's rise to power, the family fled to Amsterdam in 1936. Zucker-Franklin attended secondary school there and was a classmate of Anne Frank. In 1943, during the German occupation of the Netherlands, Zucker-Franklin was captured and interned in a camp; after their release, the family spent the next few years in hiding. During this time, Zucker-Franklin developed a friendship with a boy with
type 1 diabetes Type 1 diabetes (T1D), formerly known as juvenile diabetes, is an autoimmune disease that originates when cells that make insulin (beta cells) are destroyed by the immune system. Insulin is a hormone required for the cells to use blood sugar for ...
, which sparked her interest in medicine. In 1948 the family fled to the United States, settling in New York. Zucker-Franklin entered
Hunter College Hunter College is a public university in New York City. It is one of the constituent colleges of the City University of New York and offers studies in more than one hundred undergraduate and postgraduate fields across five schools. It also admi ...
and graduated with a bachelor's degree in language in 1952. She went on to pursue a medical degree at
New York Medical College New York Medical College (NYMC or New York Med) is a private medical school in Valhalla, New York. Founded in 1860, it is a member of the Touro College and University System. NYMC offers advanced degrees through its three schools: the School o ...
, graduating in 1956. In April 1943, shortly before going into hiding with her family in Nazi-occupied Amsterdam, she had her photograph taken by Annemie Wolff.


Career

Zucker-Franklin completed her internship at
Philadelphia General Hospital The Blockley Almshouse, later known as Philadelphia General Hospital, was a charity hospital and poorhouse located in West Philadelphia. It originally opened in 1732/33 in a different part of the city as the Philadelphia Almshouse (not to be conf ...
and her
residency Residency may refer to: * Domicile (law), the act of establishing or maintaining a residence in a given place ** Permanent residency, indefinite residence within a country despite not having citizenship * Residency (medicine), a stage of postgrad ...
at Montefiore Hospital. During residency she developed an interest in hematology, and carried out studies on coagulation factors and
lymphocyte A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. Lymphocytes include natural killer cells (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic ad ...
immunology. Later she studied
electron microscopy An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination. As the wavelength of an electron can be up to 100,000 times shorter than that of visible light photons, electron microscopes have a hi ...
at
New York University New York University (NYU) is a private research university in New York City. Chartered in 1831 by the New York State Legislature, NYU was founded by a group of New Yorkers led by then-Secretary of the Treasury Albert Gallatin. In 1832, the ...
. The use of electron microscopy to study blood cells would become a central theme of her research. Through this technique she worked to elucidate the mechanisms of phagocytosis and the structure and function of
white blood cells White blood cells, also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from mult ...
, platelets and megakaryocytes. Zucker-Franklin also collaborated with her husband,
Edward C. Franklin Edward Claus Franklin (April 14, 1928 – February 20, 1982) was a pioneering American immunologist and physician. He made major gains in the study of the aging process with contributions that led to the discovery of a group of abnormal protein ...
, in studies on amyloid protein. In 1963, Zucker-Franklin began working as an assistant professor at the
New York University School of Medicine NYU Grossman School of Medicine is a medical school of New York University, a private research university in New York City. It was founded in 1841 and is one of two medical schools of the university, with the other being the Long Island School of ...
. She became full professor in 1974. In 1981, Zucker-Franklin served as president of the Society for Leukocyte Biology. That year she published the first edition of ''Atlas of Blood Cells: Function and Pathology'' in collaboration with
Carlo Grossi Carlo Grossi (c. 163414 May 1688) was an Italian composer. Life He is believed to have been the first composer to use the term "divertimento", in his 1681 composition ''Il divertimento de' grandi musiche da camera, ò per servizio di tavola.'' ...
; the textbook, extensively illustrated with electron micrographs, has been called "the finest in its class". In 1995, Zucker-Franklin was elected president of the
American Society of Hematology The American Society of Hematology (ASH) is a professional organization representing hematologists. It was founded in 1958. Its annual meeting is held in December of every year and has attracted more than 30,000 attendees. The society publishes th ...
and became a member of the National Academy of Medicine. She was awarded an honorary PhD by the
City University of New York The City University of New York ( CUNY; , ) is the Public university, public university system of Education in New York City, New York City. It is the largest urban university system in the United States, comprising 25 campuses: eleven Upper divis ...
in 1996 and was made a fellow of the
American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...
in 2001.


Personal life and death

In 1956, Zucker-Franklin married Edward C. Franklin, who was then a medical researcher at the Rockefeller Institute. Zucker-Franklin had been friends with Edward during her childhood in Berlin. The couple had a daughter in 1964. They owned a farm together, enjoyed collecting sculptures, and collaborated on medical research until Franklin's death in 1982. On November 24, 2015, Zucker-Franklin died at her home in Manhattan, New York.


Selected publications


Articles

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Books

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Notes


References

{{Authority control 1929 births 2015 deaths Hunter College alumni New York Medical College alumni New York University Grossman School of Medicine faculty Scientists from Berlin Fellows of the American Academy of Arts and Sciences Members of the National Academy of Medicine American hematologists Women hematologists Presidents of the American Society of Hematology