The Dominguez Canyon Wilderness is a U.S. Wilderness Area located southeast of Grand Junction in western Colorado. The wilderness area established in 2009, the largest BLM roadless area in the state of Colorado, includes two major canyon systems that drain the northeastern corner of the Uncompahgre Plateau. The Wilderness Area is a portion of the larger Dominguez-Escalante National Conservation Area, in size.

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Wilderness areas of Colorado Protected areas established in 2009 Protected areas of Mesa County, Colorado Protected areas of Delta County, Colorado Bureau of Land Management areas in Colorado 2009 establishments in Colorado {{Colorado-protected-area-stub