Dock5 (
Dedicator
of
cyto
kinesis 5), also known as DOCK5, is a large (~180 kDa)
protein involved in
intracellular signalling networks.
It is a member of the DOCK-A subfamily of the
DOCK
A dock (from Dutch language, Dutch ''dok'') is the area of water between or next to one or a group of human-made structures that are involved in the handling of boats or ships (usually on or near a shore) or such structures themselves. The ex ...
family of
guanine nucleotide exchange factors (GEFs) which function as activators of small
G proteins.
Dock5 is predicted to activate the small G protein
Rac
RAC or Rac may refer to:
Organizations
* Radio Amateurs of Canada
* RATCH-Australia Corporation, electricity generator
* Refugee Action Collective (Victoria), Melbourne, Australia
* Religious Action Center of Reform Judaism, US
* Rent-A-Center, ...
.
Function
Dock5 shares significant
sequence identity with Dock180, the archetypal member of the DOCK family. It is therefore predicted to partake in similar
interactions
Interaction is action that occurs between two or more objects, with broad use in philosophy and the sciences. It may refer to:
Science
* Interaction hypothesis, a theory of second language acquisition
* Interaction (statistics)
* Interactions o ...
although this has yet to be demonstrated. Indeed, the function and signalling properties of Dock5 are poorly understood thus far. Dock5 has been identified as a crucial signalling protein in
osteoclasts
An osteoclast () is a type of bone cell that breaks down bone tissue. This function is critical in the maintenance, repair, and remodeling of bones of the vertebral skeleton. The osteoclast disassembles and digests the composite of hydrated prote ...
,
and suppression of Dock5
expression with
shRNA has been shown to inhibit survival and
differentiation of osteoclast precursor cells.
In addition, a mutation in Dock5 has been associated with the rupture of
murine lens
cataracts.
In
zebrafish Dock5 has been implicated in
myoblast fusion.
References
Further reading
*
*
*
*
GTP-binding protein regulators
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