''Dobrava-Belgrade orthohantavirus'' (DOBV), also known as Dobrava virus, is an enveloped,
single-stranded
When referring to DNA transcription, the coding strand (or informational strand) is the DNA strand whose base sequence is identical to the base sequence of the RNA transcript produced (although with thymine replaced by uracil). It is this stra ...
,
negative-sense
In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complementarity (molecular biology), complement in specifying a sequence of am ...
RNA virus species of Old World ''
Orthohantavirus
''Orthohantavirus'' is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family '' Hantaviridae'' within the order ''Bunyavirales''. Members of this genus may be called orthohantaviruses or simply hantaviruses.
Orthohantav ...
''. It is one of several species of Hantavirus that is the causative agent of severe
Hantavirus hemorrhagic fever with renal syndrome
Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses caused by species of hantaviruses. It is also known as Korean hemorrhagic fever and epidemic hemorrhagic fever. It is found in Europe, Asia, and A ...
. It was first isolated in 1985 from a
yellow-necked mouse
The yellow-necked mouse (''Apodemus flavicollis''), also called yellow-necked field mouse, yellow-necked wood mouse, and South China field mouse, is closely related to the wood mouse, with which it was long confused. It was only recognised as a ...
(''Apodemus flavicollis'') found in the village of
Dobrava, southeastern
Slovenia
Slovenia ( ; sl, Slovenija ), officially the Republic of Slovenia (Slovene: , abbr.: ''RS''), is a country in Central Europe. It is bordered by Italy to the west, Austria to the north, Hungary to the northeast, Croatia to the southeast, an ...
. It was subsequently isolated in striped field mice in Russia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown.
Phylogeny
Four genotypes are described:
* Dobrava, observed mostly in southeastern Europe
* Kurkino, observed throughout northern and eastern Europe
* Saaremaa, observed in Estonia and Slovakia
* Sochi, observed in the Black Sea coast region of Russia
Disease
Clinical presentation varies between the four genotypes. Dobrava is the most virulent, with a case-fatality rate (CFR) of 10 to 12%, followed by Sochi, which has a CFR greater than 6%, then Kurkino, which has a CFR 0.3% to 0.9%, and lastly Saaremaa, which seems to mainly be subclinical as illness has not been reported despite a relatively high rate of seropositivity.
Natural reservoir
The four genotypes each have their own
natural reservoir
In infectious disease ecology and epidemiology, a natural reservoir, also known as a disease reservoir or a reservoir of infection, is the population of organisms or the specific environment in which an infectious pathogen naturally lives and r ...
:
* Dobrava:
Yellow-necked mouse
The yellow-necked mouse (''Apodemus flavicollis''), also called yellow-necked field mouse, yellow-necked wood mouse, and South China field mouse, is closely related to the wood mouse, with which it was long confused. It was only recognised as a ...
* Kurkino:
Striped field mouse
* Saaremaa:
Striped field mouse
* Sochi:
Black Sea field mouse
The Black Sea field mouse (''Apodemus ponticus'') is a species of rodent in the family Muridae.
It is found in Armenia, Azerbaijan, Georgia, possibly Iran, Iraq, Russian Federation, and Turkey
Turkey ( tr, Türkiye ), officially the Re ...
See also
*
Hantavirus vaccine Hantavirus vaccine is a vaccine that protects in humans against hantavirus infections causing hantavirus hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome
Hantavirus pulmonary syndrome (HPS) is one of two potentially fa ...
*
Sangassou virus
''Sangassou orthohantavirus'' (SANGV) is single-stranded, negative-sense RNA virus species of the genus ''Orthohantavirus'' in the ''Bunyavirales'' order. It was first isolated in an African wood mouse ('' Hylomyscus simus'') in the forest in Gu ...
*
Conjunctival suffusion
Conjunctival suffusion is an eye finding occurring early in leptospirosis, which is caused by ''Leptospira interrogans''. Conjunctival suffusion is characterized by redness of the conjunctiva that resembles conjunctivitis, but it does not invo ...
*
List of cutaneous conditions
*
Sweating sickness
Sweating sickness, also known as the sweats, English sweating sickness, English sweat or ''sudor anglicus'' in Latin, was a mysterious and contagious disease that struck England and later continental Europe in a series of epidemics beginning ...
, which may have been caused by a hantavirus
*
1993 Four Corners hantavirus outbreak
References
External links
Sloan Science and Film / Short Films / Muerto Canyonby Jen Peel 29 minutes
by Brian Hjelle, M.D., Department of Pathology, School of Medicine, University of New Mexico
Virus Pathogen Database and Analysis Resource (ViPR): Bunyaviridae
{{Taxonbar, from=Q29002493
Viral diseases
Hantaviridae
Hemorrhagic fevers
Rodent-carried diseases