Diverted total synthesis in

chemistry Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...

is a strategy in

drug discovery In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by ...

aiming at

organic synthesis Organic synthesis is a special branch of chemical synthesis and is concerned with the intentional construction of organic compounds. Organic molecules are often more complex than inorganic compounds, and their synthesis has developed into one o ...

natural product A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical syn ...

analogues rather than the natural product itself. The target can be the modification of a natural product or the modification of an intermediate. In this sense it differs from other strategies such as total synthesis and

semisynthesis Semisynthesis, or partial chemical synthesis, is a type of chemical synthesis that uses chemical compounds isolated from natural sources (such as microbial cell cultures or plant material) as the starting materials to produce novel compounds with ...

. The purpose can be gaining a scientific understanding of the

biological activity In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter. When a drug is a complex chemical mixture, this activity is exerted by the substance's active ingredient or ...

of the original natural product or the discovery of new drugs with the same biological activity but simpler to produce. The concept was introduced by

Samuel J. Danishefsky Samuel J. Danishefsky (born March 10, 1936) is an American chemist working as a professor at both Columbia University and the Memorial Sloan-Kettering Cancer Center in New York City. Birth and education Samuel J. Danishefsky was born in 1936 in ...

in 2006. Notable examples of this strategy are the potential drug

ixabepilone Ixabepilone (INN; also known as azaepothilone B, codenamed BMS-247550) is a pharmaceutical drug developed by Bristol-Myers Squibb as a chemotherapeutic medication for cancer. History Ixabepilone is a semi-synthetic analog of epothilone B, a natura ...

which is an analogue of the natural product

epothilone B Epothilones are a class of potential cancer drugs. Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials, epothilones have better efficacy and milder adverse effects than taxanes. , epothilones A t ...

and

carfilzomib Carfilzomib, sold under the brand name Kyprolis, is an anti-cancer medication acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin. It was developed by Onyx Pharmaceuticals. The U. ...

which is derived from

epoxomicin Epoxomicin is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity. It was originally discovered in 1992.eravacycline derived from tetracycline. Cabergoline is derived from a number of ergot alkaloids one of which is

lysergic acid Lysergic acid, also known as -lysergic acid and (+)-lysergic acid, is a precursor for a wide range of ergoline alkaloids that are produced by the ergot fungus and found in the seeds of '' Turbina corymbosa'' (ololiuhqui), '' Argyreia nervosa'' ...

and Simvastatin is based on Lovastatin. Diverted total synthesis is a topic in academic research.

References

{{reflist, colwidth=60em , refs= ''Design and synthesis of analogues of natural products'' Martin E. Maiera Org. Biomol. Chem., 2015,13, 5302-5343 {{doi, 10.1039/C5OB00169B ''Small Molecule Natural Products in the Discovery of Therapeutic Agents: The Synthesis Connection'' Rebecca M. Wilson‡ and Samuel J. Danishefsky*,‡,§ The Journal of Organic Chemistry 2006 71 (22), 8329-8351 {{doi, 10.1021/jo0610053 Fürstner, A. (2011), ''From Total Synthesis to Diverted Total Synthesis: Case Studies in the Amphidinolide Series''. Isr. J. Chem., 51: 329–345. {{doi, 10.1002/ijch.201100006 ''Diverted total synthesis: Preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties'' Alois Fürstner, Douglas Kirk, Michaël D. B. Fenster, Christophe Aïssa, Dominic De Souza, and Oliver Müller PNAS vol. 102 no. 23 8103–8108 2005, {{doi, 10.1073/pnas.0501441102 Lei, X. and Danishefsky, Samuel J. (2008), ''Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition''. Adv. Synth. Catal., 350: 1677–1681. {{doi, 10.1002/adsc.200800187 ''Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog'' Thordur Oskarsson, Pavel Nagorny, Isaac J. Krauss, Lucy Perez, Mihirbaran Mandal, Guangli Yang, Ouathek Ouerfelli, Danhua Xiao, Malcolm A. S. Moore, Joan Massagué, and Samuel J. Danishefsky Journal of the American Chemical Society 2010 132 (9), 3224-3228 {{doi, 10.1021/ja9101503 ''Synthetic studies toward (+)-cortistatin'' A Zhang Wang, Mingji Dai, Peter K. Park Samuel J. Danishefsky Tetrahedron Volume 67, Issue 52, 30 December 2011, Pages 10249–10260 {{doi, 10.1016/j.tet.2011.10.026 ''Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity'' Paul A. Wender, Jeremy L. Baryza, Stacey E. Brenner, Brian A. DeChristopher, Brian A. Loy, Adam J. Schrier, and Vishal A. Verma Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17): 6721–6726. {{doi, 10.1073/pnas.1015270108 ''Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin'' Nicolas Lecomte, Jon T. Njardarson, Pavel Nagorny, Guangli Yang, Robert Downey, Ouathek Ouerfelli, Malcolm A. S. Moore, and Samuel J. Danishefsky Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37): 15074-15078 {{doi, 10.1073/pnas.1015247108 ''Nickel-catalyzed regiodivergent approach to macrolide motifs'' Abdur-Rafay Shareef, David H. Sherman and John Montgomery Chem. Sci., 2012,3, 892-895 {{doi, 10.1039/C2SC00866A ''Nitroso Diels-Alder (NDA) Reaction as an Efficient Tool for the Functionalization of Diene-Containing Natural Products'' Serena Carosso and Marvin J. Miller Org Biomol Chem. 2014 Oct 14; 12(38): 7445–7468 {{doi, 10.1039/c4ob01033g ''Counting on natural products for drug design'' Tiago Rodrigues, Daniel Reker, Petra Schneider & Gisbert Schneider Nature Chemistry 8, 531–541 (2016) {{doi, 10.1038/nchem.2479 Total synthesis