Dipak K. Das
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Dipak Kumar Das (1947 – September 19, 2013) was the director of the Cardiovascular Research Center at the University of Connecticut Health Center in
Farmington Farmington may refer to: Places Canada *Farmington, British Columbia *Farmington, Nova Scotia (disambiguation) United States * Farmington, Arkansas *Farmington, California * Farmington, Connecticut *Farmington, Delaware * Farmington, Georgia ...
and is known for research fraud. His work centered on the beneficial properties of
resveratrol Resveratrol (3,5,4′-trihydroxy-''trans''-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacteria or fungi. Sources ...
, which is found in
red wine Red wine is a type of wine made from dark-colored grape varieties. The color of the wine can range from intense violet, typical of young wines, through to brick red for mature wines and brown for older red wines. The juice from most purple grap ...
, but over twenty of his research papers have been since retracted. On January 11, 2012, the University of Connecticut Health Center announced that a review board has found Das guilty of 145 counts of fabrication or falsification of data; the three-year investigation examined more than seven years of activity in Das's lab, and centered on
Western blot The western blot (sometimes called the protein immunoblot), or western blotting, is a widely used analytical technique in molecular biology and immunogenetics to detect specific proteins in a sample of tissue homogenate or extract. Besides detect ...
results that had been manipulated and used in published papers. In May 2012, Das was fired from both positions at the University of Connecticut Health Center.


Biography

Das graduated from Jadavpur University and received his Ph.D. from Calcutta University in
India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...
. He joined the University of Connecticut in 1984 and received tenure in 1993. Das was a prolific publisher of research. His name appears on over 500 articles, including 117 articles on resveratrol. Das was an editor-in-chief of the journal ''Antioxidants and Redox Signaling''. He also served as associate editor of the ''American Journal of Physiology. Heart and Circulatory Physiology'' and consulting editor of ''
Molecular and Cellular Biochemistry ''Molecular and Cellular Biochemistry'' is a peer-reviewed scientific journal covering research in cellular biology and biochemistry. It was a successor to the journal ''Enzymologia'' and was established in 1973 to make "it possible to extend the p ...
''. His work on alcohol, HDL, and the heart was mentioned in ''
The New York Times ''The New York Times'' (''the Times'', ''NYT'', or the Gray Lady) is a daily newspaper based in New York City with a worldwide readership reported in 2020 to comprise a declining 840,000 paid print subscribers, and a growing 6 million paid ...
''. He also gained attention in 2009 after publishing a study on the heart benefits of crushed
garlic Garlic (''Allium sativum'') is a species of bulbous flowering plant in the genus ''Allium''. Its close relatives include the onion, shallot, leek, chive, Allium fistulosum, Welsh onion and Allium chinense, Chinese onion. It is native to South A ...
.


Data falsification investigation

Data fabrication by Das was alleged by a university investigation committee to have begun in 2005, when "there was no one in the lab with the expertise to prepare Western blots." Regarding Das' falsification of figures in his published works, in explicitly identifying 145 such cases the investigation committee reported that "many figures had more manipulations but, for expediency, the review board only noted the most obvious." The investigation report further stated that "given the large number of irregularities discovered, which were done over several years and in several different ways, the review board can only conclude that they were the result of intentional acts of data falsification and fabrication, designed to deceive." The university notified 11 scientific journals that published papers authored by Das, and the U.S. Office of Research Integrity launched an independent investigation of his work. In January 2012, University of Connecticut officials reported that dismissal proceedings were underway against Das. The Health Center terminated all research in Das's laboratory and declined federal research grants awarded to him. Following Das' dismissal, the ''Hartford Courant'' in 2013 reported that Das intended to file a $35 million defamation lawsuit against UConn. As of 2024, Das has had 24 of his research publications retracted.


See also

* List of scientific misconduct incidents


References


External links

*
Dipak Das response letter to Univ of Connecticut officials
{{DEFAULTSORT:Das, Dipak K. 1947 births 2013 deaths Ethics of science and technology Health fraud people Hoaxes in science Hoaxes in the United States Medical controversies in the United States People involved in scientific misconduct incidents