Diosmetin, also known as 5,7,3′-trihydroxy-4′-methoxyflavone, is an
''O''-methylated flavone, a chemical compound that can be found in the Caucasian
vetch
''Vicia'' is a genus of over 240 species of flowering plants that are part of the legume family (Fabaceae), and which are commonly known as vetches. Member species are native to Europe, North America, South America, Asia and Africa. Some other ...
.
Diosmetin glycosides from caucasian vetch: Isolation and study of biological activity
O. A. Andreeva, M. N. Ivashev, I. I. Ozimina and G. V. Maslikova, 1994
/ref>
It has been found to act as a weak TrkB receptor
Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the ''NTRK2'' gene. TrkB is a recepto ...
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
.
Glycosides
Diosmetin is the aglycone An aglycone (aglycon or genin) is the compound remaining after the glycosyl group on a glycoside is replaced by a hydrogen atom. For example, the aglycone of a cardiac glycoside would be a steroid molecule.
Detection
A way to identify aglycone ...
of diosmin
Diosmin (diosmetin 7-O-rutinoside), a flavone glycoside of diosmetin, is manufactured from citrus fruit peels as a phlebotonic non-prescription dietary supplement used to aid treatment of hemorrhoids or chronic venous diseases, mainly of the le ...
.
See also
* Tropomyosin receptor kinase B § Agonists
References
O-methylated flavones
Resorcinols
TrkB agonists
3-Hydroxypropenals within hydroxyquinones
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