Dinitrosyl Iron Complexes on:
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In biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
, dinitrosyl iron complexes (DNIC's) are coordination complex
A coordination complex consists of a central atom or ion, which is usually metallic and is called the ''coordination centre'', and a surrounding array of bound molecules or ions, that are in turn known as ''ligands'' or complexing agents. Many ...
es with the formula e(NO)2(SR)2sup>−. Together with Roussin esters (Fe2(NO)4(SR)2), they result from the degradation of iron-sulfur proteins by nitric oxide
Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula . It is one of the principal oxides of nitrogen. Nitric oxide is a free radical: it has an unpaired electron, which is sometimes denoted by a dot in its che ...
. Commonly the thiolate ligands are cysteinyl residues or glutathione. These metal nitrosyl complex
Sodium nitroprusside, a medicinally significant metal nitrosyl-pentacyanoferrate (Fe-III) compound, used to treat hypertension.
Metal nitrosyl complexes are complex (chemistry), complexes that contain nitric oxide, NO, bonded to a transition me ...
es have attracted much attention because they serve as biochemical signals in response to oxidative stress, manifested in the formation of NO. The anions are tetrahedral.
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