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In molecular biology, the DinI-like protein family is a family of short
proteins Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
. The family includes DNA-damage-inducible protein I (DinI) and related proteins. The SOS response, a set of cellular phenomena exhibited by eubacteria, is initiated by various causes that include DNA damage-induced replication arrest, and is positively regulated by the co- protease activity of RecA. '' Escherichia coli'' DinI, a LexA-regulated
SOS gene The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis is induced. The system involves the RecA protein (RAD51, Rad51 in eukaryotes). The RecA protein, stimulated by single-stranded ...
product, shuts off the initiation of the SOS response when overexpressed '' in vivo''.
Biochemical Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology an ...
and genetic studies indicated that DinI physically interacts with RecA to inhibit its co-protease activity. The
structure A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such as ...
of DinI is known.


References

Protein families {{protein-stub