Dihydroorotase (, ''carbamoylaspartic dehydrase'', ''dihydroorotate hydrolase'') is an enzyme which converts

carbamoyl aspartic acid Carbamoyl aspartic acid (or ureidosuccinic acid) is a carbamate derivative, serving as an intermediate in pyrimidine biosynthesis Pyrimidine (; ) is an aromatic, heterocyclic, organic compound similar to pyridine (). One of the three diazines ...

into 4,5-dihydroorotic acid in the biosynthesis of

pyrimidines Pyrimidine (; ) is an aromatic, heterocyclic, organic compound similar to pyridine (). One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has nitrogen atoms at positions 1 and 3 in the ring. The other ...

. It forms a multifunctional enzyme with

carbamoyl phosphate synthetase Carbamoyl phosphate synthetase catalyzes the ATP-dependent synthesis of carbamoyl phosphate from glutamine () or ammonia () and bicarbonate. This enzyme catalyzes the reaction of ATP and bicarbonate to produce carboxy phosphate and ADP. Carb ...

and

aspartate transcarbamoylase Aspartate carbamoyltransferase (also known as aspartate transcarbamoylase or ATCase) catalyzes the first step in the pyrimidine biosynthetic pathway (). In '' E. coli'', the enzyme is a multi- subunit protein complex composed of 12 subunits (3 ...

. Dihydroorotase is a

zinc Zinc is a chemical element with the symbol Zn and atomic number 30. Zinc is a slightly brittle metal at room temperature and has a shiny-greyish appearance when oxidation is removed. It is the first element in group 12 (IIB) of the periodi ...

metalloenzyme Metalloprotein is a generic term for a protein that contains a metal ion cofactor. A large proportion of all proteins are part of this category. For instance, at least 1000 human proteins (out of ~20,000) contain zinc-binding protein domains al ...

References

External links

* * EC 3.5.2 {{transferase-stub

See also

References

External links