Dienestrol (, ) (brand names Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol, numerous others), also known as dienoestrol (), is a

synthetic Synthetic things are composed of multiple parts, often with the implication that they are artificial. In particular, 'synthetic' may refer to: Science * Synthetic chemical or compound, produced by the process of chemical synthesis * Synthetic o ...

nonsteroidal estrogen of the stilbestrol group which is or was used to treat menopausal symptoms in the United States and Europe. It has been studied for use by rectal administration in the treatment of

prostate cancer Prostate cancer is cancer of the prostate. Prostate cancer is the second most common cancerous tumor worldwide and is the fifth leading cause of cancer-related mortality among men. The prostate is a gland in the male reproductive system that sur ...

in men as well. The medication was introduced in the U.S. in 1947 by Schering as Synestrol and in France in 1948 as Cycladiene. Dienestrol is a close analogue of diethylstilbestrol. It has approximately 223% and 404% of the affinity of estradiol at the ERα and ERβ, respectively.

Dienestrol diacetate Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol. It is an ester of dienestrol. See also * List of estrogen esters § Esters of ot ...

(brand names Faragynol, Gynocyrol, others) also exists and has been used medically.

Isomers

Dienestrol structure.svg, Dienestrol (unspecified) - CA
84-17-3
E,E-Dienestrol structure.svg, ''E'',''E''-Dienestrol - CA
13029-44-2
Z,Z-Dienestrol structure.svg, ''Z'',''Z''-Dienestrol - CA
35495-11-5

References

Abandoned drugs Phenols Stilbenoids Synthetic estrogens {{Genito-urinary-drug-stub