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Calcium pyrophosphate (Ca2P2O7) is a chemical compound, an insoluble calcium salt containing the
pyrophosphate In chemistry, pyrophosphates are phosphorus oxyanions that contain two phosphorus atoms in a P–O–P linkage. A number of pyrophosphate salts exist, such as disodium pyrophosphate (Na2H2P2O7) and tetrasodium pyrophosphate (Na4P2O7), among other ...
anion. There are a number of forms reported: an anhydrous form, a dihydrate, Ca2P2O7·2H2O and a tetrahydrate, Ca2P2O7·4H2O. Deposition of dihydrate crystals in cartilage are responsible for the severe joint pain in cases of
calcium pyrophosphate deposition disease Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a rheumatologic disease which is thought to be secondary to abnormal accumulation of calcium pyrophosphate dihydrate cry ...
(pseudo gout) whose symptoms are similar to those of
gout Gout ( ) is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot and swollen joint, caused by deposition of monosodium urate monohydrate crystals. Pain typically comes on rapidly, reaching maximal intensit ...
. Ca2P2O7 is commonly used as a mild abrasive agent in
toothpaste Toothpaste is a paste or gel dentifrice used with a toothbrush to clean and maintain the aesthetics and health of teeth. Toothpaste is used to promote oral hygiene: it is an abrasive that aids in removing dental plaque and food from the teeth, a ...
s, because of its insolubility and nonreactivity toward fluoride. __TOC__


Preparation

Crystals of the tetrahydrate can be prepared by reacting
sodium pyrophosphate Tetrasodium pyrophosphate, also called sodium pyrophosphate, tetrasodium phosphate or TSPP, is an inorganic compound with the chemical formula, formula Na4P2O7. As a salt, it is a white, water-soluble solid. It is composed of pyrophosphate anion an ...
, Na4P2O7 with
calcium nitrate Calcium nitrate, also called ''Norgessalpeter'' (Norwegian salpeter), is an inorganic compound with the formula Ca(NO3)2(H2O)x. The anhydrous compound, which is rarely encountered, absorbs moisture from the air to give the tetrahydrate. Both anhyd ...
, Ca(NO3)2, at carefully controlled pH and temperature: :Na4P2O7(aq)+2 Ca(NO3)2(aq)→ Ca2P2O7·4 H2O + 4 NaNO3 The dihydrate, sometimes termed CPPD, can be formed by the reaction of
pyrophosphoric acid Pyrophosphoric acid, also known as diphosphoric acid, is the inorganic compound with the formula H4P2O7 or, more descriptively, HO)2P(O)sub>2O. Colorless and odorless, it is soluble in water, diethyl ether, and ethyl alcohol. The anhydrous acid cr ...
with
calcium chloride Calcium chloride is an inorganic compound, a salt with the chemical formula . It is a white crystalline solid at room temperature, and it is highly soluble in water. It can be created by neutralising hydrochloric acid with calcium hydroxide. Ca ...
: :CaCl2 + H4P2O7(aq) → Ca2P2O7·2 H2O + HCl. The anhydrous forms can be prepared by heating
dicalcium phosphate Dicalcium phosphate is the calcium phosphate with the formula CaHPO4 and its dihydrate. The "di" prefix in the common name arises because the formation of the HPO42– anion involves the removal of two protons from phosphoric acid, H3PO4. It is al ...
: :2 CaHPO4 → Ca2P2O7 + H2O At 240-500 °C an amorphous phase is formed, heating to 750 °C forms β-Ca2P2O7, heating to 1140 - 1350 °C forms the α-Ca2P2O7.


Structure of anhydrous and hydrated forms

The stable tetrahydrate was originally reported to be rhombohedral but is now believed to be monoclinic. Additionally there is an unstable monoclinic form. The dihydrate is triclinic, with hydrogen bonding between the two water molecules and hydrogen bonds to the O atoms on the anion. An hexagonal dihydrate has also been reported. The anhydrous form has 3 polymorphs, α-, β-, and metastable γ (Tα/β=1140ºС). The high temperature form α- is monoclinic (''P21/n, a=12.66(1)Å, b=8.542(8)Å, c=5.315(5)Å, Z=4, ρα=2.95 g/cm3)'', with 8 coordinate calcium, the lower temperature form β- is tetragonal (''P41,'' a=b=6.684Å, c=24.144Å, V=915.40Å3, Z=8, ρβ=3.128 g/cm3), with calcium in four different coordination environments, 2 that are 7 coordinate, one eight and one 9. In both the pyrophosphates are essentially eclipsed.


References

{{DEFAULTSORT:Calcium Pyrophosphate Calcium compounds Pyrophosphates Phosphates ja:ピロリン酸カルシウム